YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon [Bos taurus (cattle)] - Gene

Summary

Official Symbol: YWHAEprovided by VGNC
Official Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilonprovided by VGNC
Primary source: VGNC:VGNC:37045
See related: BGD:BT17005; Ensembl:ENSBTAG00000005664
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all

Genomic context

Location:: chromosome: 19

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	ARS-UCD1.2 (GCF_002263795.1)	19	NC_037346.1 (22513993..22548938, complement)
105	previous assembly	Bos_taurus_UMD_3.1.1 (GCF_000003055.6)	19	AC_000176.1 (23086221..23121185, complement)

Chromosome 19 - NC_037346.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Pathways from BioSystems

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AURKA Activation by TPX2, organism-specific biosystem (from REACTOME)
AURKA Activation by TPX2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of BAD and translocation to mitochondria, organism-specific biosystem (from REACTOME)
Activation of BAD and translocation to mitochondria, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of BH3-only proteins, organism-specific biosystem (from REACTOME)
Activation of BH3-only proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Anchoring of the basal body to the plasma membrane, organism-specific biosystem (from REACTOME)
Anchoring of the basal body to the plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptosis, organism-specific biosystem (from REACTOME)
Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
Cell Cycle, organism-specific biosystem (from WikiPathways)
Cell Cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
Cell Cycle Checkpoints, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell cycle, organism-specific biosystem (from KEGG)
Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Cell cycle, conserved biosystem (from KEGG)
Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cellular response to heat stress, organism-specific biosystem (from REACTOME)
Cellular response to heat stress, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cellular responses to stress, organism-specific biosystem (from REACTOME)
Cellular responses to stress, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Centrosome maturation, organism-specific biosystem (from REACTOME)
Centrosome maturation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, organism-specific biosystem (from REACTOME)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cilium Assembly, organism-specific biosystem (from REACTOME)
Cilium Assembly, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
Epstein-Barr virus infection, conserved biosystem (from KEGG)
Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
G2/M Checkpoints, organism-specific biosystem (from REACTOME)
G2/M Checkpoints, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G2/M DNA damage checkpoint, organism-specific biosystem (from REACTOME)
G2/M DNA damage checkpoint, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G2/M Transition, organism-specific biosystem (from REACTOME)
G2/M Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
Generic Transcription Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
HSF1 activation, organism-specific biosystem (from REACTOME)
HSF1 activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hippo signaling pathway, organism-specific biosystem (from KEGG)
Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
Hippo signaling pathway, conserved biosystem (from KEGG)
Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
Intrinsic Pathway for Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Loss of Nlp from mitotic centrosomes, organism-specific biosystem (from REACTOME)
Loss of Nlp from mitotic centrosomes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystem (from REACTOME)
Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Membrane Trafficking, organism-specific biosystem (from REACTOME)
Membrane Trafficking, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
Mitotic G2-G2/M phases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
NADE modulates death signalling, organism-specific biosystem (from REACTOME)
NADE modulates death signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
Neurotrophin signaling pathway, conserved biosystem (from KEGG)
Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
Oocyte meiosis, organism-specific biosystem (from KEGG)
Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
Oocyte meiosis, conserved biosystem (from KEGG)
Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
Organelle biogenesis and maintenance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
Programmed Cell Death, organism-specific biosystem (from REACTOME)
Programmed Cell Death, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystem (from REACTOME)
RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
RHO GTPase Effectors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RHO GTPases activate PKNs, organism-specific biosystem (from REACTOME)
RHO GTPases activate PKNs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystem (from REACTOME)
Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of HSF1-mediated heat shock response, organism-specific biosystem (from REACTOME)
Regulation of HSF1-mediated heat shock response, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystem (from REACTOME)
Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Hippo, organism-specific biosystem (from REACTOME)
Signaling by Hippo, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
Signaling by Rho GTPases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TP53 Regulates Metabolic Genes, organism-specific biosystem (from REACTOME)
TP53 Regulates Metabolic Genes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
Transcriptional Regulation by TP53, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Translocation of GLUT4 to the plasma membrane, organism-specific biosystem (from REACTOME)
Translocation of GLUT4 to the plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
Vesicle-mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Viral carcinogenesis, organism-specific biosystem (from KEGG)
Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Viral carcinogenesis, conserved biosystem (from KEGG)
Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
p75 NTR receptor-mediated signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH70591 (e-PCR)
- UniSTS:88866

G19934 (e-PCR)
- UniSTS:20584

YWHAE__1220 (e-PCR)
- UniSTS:277870

RH66862 (e-PCR)
- UniSTS:85955

Homology

Homologs of the YWHAE gene: The YWHAE gene is conserved in human, chimpanzee, dog, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 220 organisms have orthologs with human gene YWHAE
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
calcium channel regulator activity	IEA Inferred from Electronic Annotation more info
histone deacetylase binding	IEA Inferred from Electronic Annotation more info
identical protein binding	IEA Inferred from Electronic Annotation more info
ion channel binding	IEA Inferred from Electronic Annotation more info
phosphoserine residue binding	IEA Inferred from Electronic Annotation more info
potassium channel regulator activity	IEA Inferred from Electronic Annotation more info
protein domain specific binding	IEA Inferred from Electronic Annotation more info
protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
scaffold protein binding	IEA Inferred from Electronic Annotation more info
ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
cellular response to heat	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of calcium ion export across plasma membrane	IEA Inferred from Electronic Annotation more info
negative regulation of calcium ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
negative regulation of peptidyl-serine dephosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of protein export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
protein localization to nucleus	ISS Inferred from Sequence or Structural Similarity more info
regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
regulation of membrane repolarization	IEA Inferred from Electronic Annotation more info
regulation of potassium ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
melanosome	IEA Inferred from Electronic Annotation more info
nucleus	ISS Inferred from Sequence or Structural Similarity more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 14-3-3 protein epsilon

Names: 14-3-3E; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174491.3 → NP_776916.1 14-3-3 protein epsilon

See identical proteins and their annotated locations for NP_776916.1

Status: PROVISIONAL

Source sequence(s)

BC102928

UniProtKB/Swiss-Prot

P62261

Related

ENSBTAP00000007442.5, ENSBTAT00000007442.5

Conserved Domains (1) summary

cd10020
Location:4 → 233

14-3-3_epsilon; 14-3-3 epsilon, an isoform of 14-3-3 protein

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

NC_037346.1 Reference ARS-UCD1.2 Primary Assembly

Range

22513993..22548938 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005220066.3 → XP_005220123.1 14-3-3 protein epsilon isoform X2

See identical proteins and their annotated locations for XP_005220123.1

Conserved Domains (1) summary

cd10020
Location:4 → 233

14-3-3_epsilon; 14-3-3 epsilon, an isoform of 14-3-3 protein
XM_024979616.1 → XP_024835384.1 14-3-3 protein epsilon isoform X1

Conserved Domains (1) summary

cd10020
Location:4 → 233

14-3-3_epsilon; 14-3-3 epsilon, an isoform of 14-3-3 protein