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SFTPC surfactant protein C [ Bos taurus (cattle) ]

Gene ID: 282071, updated on 5-Mar-2024

Summary

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Official Symbol
SFTPCprovided by VGNC
Official Full Name
surfactant protein Cprovided by VGNC
Primary source
VGNC:VGNC:34529
See related
BGD:BT10885; Ensembl:ENSBTAG00000012560
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See SFTPC in Genome Data Viewer
Location:
chromosome: 8
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (69471143..69477940)

Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene receptor accessory protein 4 Neighboring gene leucine rich repeat LGI family member 3 Neighboring gene bone morphogenetic protein 1 Neighboring gene phytanoyl-CoA 2-hydroxylase interacting protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein sequence analysis studies on the low molecular weight hydrophobic proteins associated with bovine pulmonary surfactant. Olafson RW, et al. Biochem Biophys Res Commun, 1987 Nov 13. PMID 3689402
  2. Characterization of the small hydrophobic proteins associated with pulmonary surfactant. Yu SH, et al. Biochim Biophys Acta, 1987 Oct 17. PMID 3663690
  3. Lung surfactant protein SP-C from human, bovine, and canine sources contains palmityl cysteine thioester linkages. Stults JT, et al. Am J Physiol, 1991 Aug. PMID 1872406
  4. Hydrophobic surfactant proteins induce a phosphatidylethanolamine to form cubic phases. Chavarha M, et al. Biophys J, 2010 Apr 21. PMID 20409474, Free PMC Article
  5. Hydrophobic 3.7 kDa surfactant polypeptide: structural characterization of the human and bovine forms. Johansson J, et al. FEBS Lett, 1988 May 9. PMID 3366248

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The hydrophobic surfactant proteins SP-B and SP-C induce formation of bicontinuous inverse cubic phases.
    Title: Hydrophobic surfactant proteins induce a phosphatidylethanolamine to form cubic phases.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in respiratory gaseous exchange by respiratory system IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in alveolar lamellar body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pulmonary surfactant-associated protein C
Names
SP-C
pulmonary surfactant-associated proteolipid SPL(Val)
surfactant, pulmonary-associated protein C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174462.4 → NP_776887.1  pulmonary surfactant-associated protein C

    See identical proteins and their annotated locations for NP_776887.1

    Status: PROVISIONAL

    Source sequence(s)
    BC123536
    UniProtKB/Swiss-Prot
    A4FV06, P15783, P15784, Q9BDX5
    Related
    ENSBTAP00000016672.4, ENSBTAT00000016672.5
    Conserved Domains (3) summary
    smart00019
    Location:1 → 189
    SF_P; Pulmonary surfactant proteins
    pfam04089
    Location:99 → 189
    BRICHOS; BRICHOS domain
    pfam08999
    Location:1 → 93
    SP_C-Propep; Surfactant protein C, N terminal propeptide

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    69471143..69477940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059888962.1 → XP_059744945.1  pulmonary surfactant-associated protein C isoform X1

    Related
    ENSBTAP00000099995.1, ENSBTAT00000123665.1

  2. XM_015472573.3 → XP_015328059.1  pulmonary surfactant-associated protein C isoform X2

    Conserved Domains (3) summary
    smart00019
    Location:22 → 169
    SF_P; Pulmonary surfactant proteins
    pfam04089
    Location:90 → 169
    BRICHOS; BRICHOS domain
    pfam08999
    Location:22 → 90
    SP_C-Propep; Surfactant protein C, N terminal propeptide
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15783.3 GenPept UniProtKB/Swiss-Prot:P15783

Gene LinkOut

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