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Dhrs4 dehydrogenase/reductase (SDR family) member 4 [ Mus musculus (house mouse) ]

Gene ID: 28200, updated on 31-Jan-2019

Summary

Official Symbol
Dhrs4provided by MGI
Official Full Name
dehydrogenase/reductase (SDR family) member 4provided by MGI
Primary source
MGI:MGI:90169
See related
Ensembl:ENSMUSG00000022210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CR; RRD; NDRD; PHCR; PSCD; mouNRDR; AI043103; AI790593; D14Ucla2
Expression
Ubiquitous expression in kidney adult (RPKM 28.9), liver E18 (RPKM 24.8) and 28 other tissues See more

Genomic context

See Dhrs4 in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (55478736..55490340)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (56097595..56109177)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene myosin light polypeptide 6 alkali smooth muscle and non-muscle protein, pseudogene Neighboring gene predicted gene, 41158 Neighboring gene capping protein regulator and myosin 1 linker 3 Neighboring gene copine VI

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the Dhrs4 gene: The Dhrs4 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3-keto sterol reductase activity ISO
Inferred from Sequence Orthology
more info
 
alcohol dehydrogenase [NAD(P)+] activity ISO
Inferred from Sequence Orthology
more info
 
carbonyl reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
Inferred from Sequence Orthology
more info
 
retinal dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
alcohol metabolic process ISO
Inferred from Sequence Orthology
more info
 
cellular ketone metabolic process ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process ISO
Inferred from Sequence Orthology
more info
 
protein tetramerization ISO
Inferred from Sequence Orthology
more info
 
retinal metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
steroid metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dehydrogenase/reductase SDR family member 4
Names
NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase
NADPH-dependent retinol dehydrogenase/reductase
peroxisomal short-chain alcohol dehydrogenase
NP_001033027.2
NP_109611.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037938.2NP_001033027.2  dehydrogenase/reductase SDR family member 4 isoform 1

    See identical proteins and their annotated locations for NP_001033027.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC159002, AK146988, BQ032668, BY291911
    Consensus CDS
    CCDS27111.1
    UniProtKB/Swiss-Prot
    Q99LB2
    UniProtKB/TrEMBL
    Q3UIB5
    Related
    ENSMUSP00000022821.6, ENSMUST00000022821.7
    Conserved Domains (2) summary
    cd08936
    Location:24279
    CR_SDR_c; Porcine peroxisomal carbonyl reductase like, classical (c) SDR
    PRK07231
    Location:31274
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional
  2. NM_030686.2NP_109611.1  dehydrogenase/reductase SDR family member 4 isoform 2

    See identical proteins and their annotated locations for NP_109611.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC159002, AK018788, AW125533, BY291911
    UniProtKB/TrEMBL
    Q9D2U3
    Related
    ENSMUSP00000154481.1, ENSMUST00000226168.1
    Conserved Domains (1) summary
    cl21454
    Location:24178
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    55478736..55490340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001781127.1 RNA Sequence

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