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GPD2 glycerol-3-phosphate dehydrogenase 2 [ Homo sapiens (human) ]

Gene ID: 2820, updated on 13-Mar-2020

Summary

Official Symbol
GPD2provided by HGNC
Official Full Name
glycerol-3-phosphate dehydrogenase 2provided by HGNC
Primary source
HGNC:HGNC:4456
See related
Ensembl:ENSG00000115159 MIM:138430
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GDH2; GPDM; mGPDH
Summary
The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
Expression
Ubiquitous expression in colon (RPKM 11.8), brain (RPKM 10.3) and 25 other tissues See more
Orthologs

Genomic context

See GPD2 in Genome Data Viewer
Location:
2q24.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (156435290..156586403)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (157291965..157442915)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tRNA-Ala (anticodon CGC) 3-1 Neighboring gene tRNA-Gly (anticodon GCC) 2-2 Neighboring gene uncharacterized LOC105373707 Neighboring gene long intergenic non-protein coding RNA 1958 Neighboring gene VISTA enhancer hs413

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Diabetes mellitus type 2
MedGen: C0011860 OMIM: 125853 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.
NHGRI GWA Catalog
Genome-wide association of lipid-lowering response to statins in combined study populations.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of glycerol-3-phosphate dehydrogenase 2 (GPD2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
glycerol-3-phosphate dehydrogenase (quinone) activity TAS
Traceable Author Statement
more info
 
sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
camera-type eye development IEA
Inferred from Electronic Annotation
more info
 
gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
glycerol catabolic process IEA
Inferred from Electronic Annotation
more info
 
glycerol-3-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
glycerophosphate shuttle TAS
Traceable Author Statement
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
glycerol-3-phosphate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glycerol-3-phosphate dehydrogenase, mitochondrial
Names
GPD-M
GPDH-M
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
mitochondrial glycerophosphate dehydrogenase
mtGPD
testicular tissue protein Li 76
NP_000399.3
NP_001076581.2
XP_005246526.1
XP_011509279.1
XP_011509280.1
XP_016859319.1
XP_024308566.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016606.2 RefSeqGene

    Range
    5927..155951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000408.5NP_000399.3  glycerol-3-phosphate dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_000399.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC011308, AC092686
    Consensus CDS
    CCDS2202.1
    UniProtKB/Swiss-Prot
    P43304
    Related
    ENSP00000409708.2, ENST00000438166.7
    Conserved Domains (2) summary
    cd00051
    Location:627689
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl25573
    Location:1599
    DAO_C; C-terminal domain of alpha-glycerophosphate oxidase
  2. NM_001083112.3NP_001076581.2  glycerol-3-phosphate dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001076581.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC011308, AC092686
    Consensus CDS
    CCDS2202.1
    UniProtKB/Swiss-Prot
    P43304
    Related
    ENSP00000308610.5, ENST00000310454.10
    Conserved Domains (2) summary
    cd00051
    Location:627689
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl25573
    Location:1599
    DAO_C; C-terminal domain of alpha-glycerophosphate oxidase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    156435290..156586403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510977.2XP_011509279.1  glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011509279.1

    UniProtKB/Swiss-Prot
    P43304
    Conserved Domains (2) summary
    cd00051
    Location:627689
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl25573
    Location:1599
    DAO_C; C-terminal domain of alpha-glycerophosphate oxidase
  2. XM_017003830.1XP_016859319.1  glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    P43304
    Conserved Domains (2) summary
    cd00051
    Location:627689
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl25573
    Location:1599
    DAO_C; C-terminal domain of alpha-glycerophosphate oxidase
  3. XM_024452798.1XP_024308566.1  glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1

    Conserved Domains (2) summary
    cd00051
    Location:627689
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl25573
    Location:1599
    DAO_C; C-terminal domain of alpha-glycerophosphate oxidase
  4. XM_005246469.2XP_005246526.1  glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005246526.1

    UniProtKB/Swiss-Prot
    P43304
    Related
    ENSP00000386425.1, ENST00000409674.5
    Conserved Domains (2) summary
    cd00051
    Location:627689
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl25573
    Location:1599
    DAO_C; C-terminal domain of alpha-glycerophosphate oxidase
  5. XM_011510978.2XP_011509280.1  glycerol-3-phosphate dehydrogenase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011509280.1

    UniProtKB/TrEMBL
    Q53T76
    Related
    ENSP00000386484.5, ENST00000409125.8
    Conserved Domains (5) summary
    PLN02464
    Location:8565
    PLN02464; glycerol-3-phosphate dehydrogenase
    cd00051
    Location:593655
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:595654
    EF-hand_7; EF-hand domain pair
    pfam16901
    Location:428551
    DAO_C; C-terminal domain of alpha-glycerophosphate oxidase
    cl21454
    Location:3573
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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