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PPARA peroxisome proliferator activated receptor alpha [ Bos taurus (domestic cattle) ]

Gene ID: 281992, updated on 1-Jan-2025

Summary

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Official Symbol
PPARAprovided by VGNC
Official Full Name
peroxisome proliferator activated receptor alphaprovided by VGNC
Primary source
VGNC:VGNC:33181
See related
BGD:BT10263; Ensembl:ENSBTAG00000008063
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
PPARalpha
Orthologs
human mouse all
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Genomic context

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See PPARA in Genome Data Viewer
Location:
chromosome: 5
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (116438915..116513812)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112446783 Neighboring gene uncharacterized LOC101903383 Neighboring gene cysteine rich DPF motif domain containing 1 Neighboring gene polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. When Two plus Two Is More than Four: Evidence for a Synergistic Effect of Fatty Acids on Peroxisome Proliferator-Activated Receptor Activity in a Bovine Hepatic Model. Busato S, et al. Genes (Basel), 2021 Aug 21. PMID 34440457, Free PMC Article
  2. PPARα signal pathway gene expression is associated with fatty acid content in yak and cattle longissimus dorsi muscle. Qin W, et al. Genet Mol Res, 2015 Nov 19. PMID 26600505
  3. Study on genetic variations of PPARα gene and its effects on thermal tolerance in Chinese Holstein. Fang W, et al. Mol Biol Rep, 2014 Mar. PMID 24469708
  4. Involvement of the peroxisome proliferator-activated receptor (PPAR) alpha in vascular response of endocannabinoids in the bovine ophthalmic artery. Romano MR, et al. Eur J Pharmacol, 2012 May 15. PMID 22429572
  5. Fine metabolic regulation in ruminants via nutrient-gene interactions: saturated long-chain fatty acids increase expression of genes involved in lipid metabolism and immune response partly through PPAR-α activation. Bionaz M, et al. Br J Nutr, 2012 Jan. PMID 21729373

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. When Two plus Two Is More than Four: Evidence for a Synergistic Effect of Fatty Acids on Peroxisome Proliferator-Activated Receptor Activity in a Bovine Hepatic Model.
    Title: When Two plus Two Is More than Four: Evidence for a Synergistic Effect of Fatty Acids on Peroxisome Proliferator-Activated Receptor Activity in a Bovine Hepatic Model.
  2. This study investigated FA composition in yaks and cattle, in order to ascertain whether a correlation between PPARalpha signal pathway genes as candidate genes and meat FA composition in yaks and cattle exists.
    Title: PPARα signal pathway gene expression is associated with fatty acid content in yak and cattle longissimus dorsi muscle.
  3. OCTN2 expression and carnitine transport in cattle, as in rodents, are regulated by PPARalpha.
    Title: Short communication: the pharmacological peroxisome proliferator-activated receptor α agonist WY-14,643 increases expression of novel organic cation transporter 2 and carnitine uptake in bovine kidney cells.
  4. In conclusion, H8H8 haplotype combination of the PPARalpha may be advantageous for heat resistance traits in Chinese Holstein cattle.
    Title: Study on genetic variations of PPARα gene and its effects on thermal tolerance in Chinese Holstein.
  5. Data suggest that PPARalpha (but not PPARgamma) is involved in vasorelaxation of ophthalmic artery in response to endocannabinoids (i.e., anandamide, palmitoylethanolamide); endothelium removal slightly decreases the response to endocannabinoids.
    Title: Involvement of the peroxisome proliferator-activated receptor (PPAR) alpha in vascular response of endocannabinoids in the bovine ophthalmic artery.
  6. Data from gene profiling experiments in bovine cell line support hypothesis that saturated long-chain fatty acids modulate ruminant lipid metabolism and expression of inflammation mediators with major effects induced via activation of PPARalpha.
    Title: Fine metabolic regulation in ruminants via nutrient-gene interactions: saturated long-chain fatty acids increase expression of genes involved in lipid metabolism and immune response partly through PPAR-α activation.
  7. The results are consistent with the hypothesis that arachidonic acid acts via PPARalpha to increase PTGS2 levels in bovine endometrial stromal cells.
    Title: Peroxisome-proliferator-activated receptors and the control of levels of prostaglandin-endoperoxide synthase 2 by arachidonic acid in the bovine uterus.
  8. Oxidized fataprevent an alcohol-induced triacylglycerol accumulation in rats possibly by upregulation of hepatic PPARalpha-responsive genes, whwereas conjugated linoleic acid does not.
    Title: Dietary oxidized fat prevents ethanol-induced triacylglycerol accumulation and increases expression of PPARalpha target genes in rat liver.
  9. Dietary trans fatty acids may affect liver lipid metabolism in post-partum dairy cows through alterations in PPARalpha gene expression.
    Title: Dietary trans octadecenoic acids upregulate the liver gene encoding peroxisome proliferator-activated receptor-alpha in transition dairy cows.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of cholesterol storage IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
peroxisome proliferator-activated receptor alpha
Names
peroxisome proliferative activated receptor, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034036.1 → NP_001029208.1  peroxisome proliferator-activated receptor alpha

    See identical proteins and their annotated locations for NP_001029208.1

    Status: PROVISIONAL

    Source sequence(s)
    BT020756
    UniProtKB/TrEMBL
    Q5EA13, Q9N129
    Conserved Domains (2) summary
    cd06932
    Location:203 → 469
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:103 → 186
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    116438915..116513812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024991367.2 → XP_024847135.1  peroxisome proliferator-activated receptor alpha isoform X3

    Conserved Domains (2) summary
    cd06932
    Location:36 → 302
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cl02596
    Location:1 → 19
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

  2. XM_005207472.5 → XP_005207529.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_005207529.1

    UniProtKB/TrEMBL
    Q5EA13, Q9N129
    Conserved Domains (2) summary
    cd06932
    Location:203 → 469
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:103 → 186
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

  3. XM_059886112.1 → XP_059742095.1  peroxisome proliferator-activated receptor alpha isoform X1

    UniProtKB/TrEMBL
    Q5EA13, Q9N129

  4. XM_010805796.4 → XP_010804098.2  peroxisome proliferator-activated receptor alpha isoform X2

    UniProtKB/TrEMBL
    F6RRC4, Q9N129
    Related
    ENSBTAP00000010606.5, ENSBTAT00000010606.6
Nucleotide Protein Strain
Heading Accession and Version

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