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Dcaf11 DDB1 and CUL4 associated factor 11 [ Mus musculus (house mouse) ]

Gene ID: 28199, updated on 31-Dec-2022

Summary

Official Symbol
Dcaf11provided by MGI
Official Full Name
DDB1 and CUL4 associated factor 11provided by MGI
Primary source
MGI:MGI:90168
See related
Ensembl:ENSMUSG00000022214 AllianceGenome:MGI:90168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GLO14; Wdr23; Dacf11; D14Ucla1; 0710008A13Rik
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Orthologous to human DCAF11 (DDB1 and CUL4 associated factor 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 65.2), kidney adult (RPKM 42.2) and 28 other tissues See more
Orthologs
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Genomic context

See Dcaf11 in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55796557..55807522)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55559125..55570065)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene neural retina leucine zipper gene Neighboring gene phosphoenolpyruvate carboxykinase 2 (mitochondrial) Neighboring gene fat storage-inducing transmembrane protein 1 Neighboring gene proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) Neighboring gene ER membrane protein complex subunit 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DDB1- and CUL4-associated factor 11
Names
WD repeat domain 23
WD repeat-containing protein 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199009.1NP_001185938.1  DDB1- and CUL4-associated factor 11

    See identical proteins and their annotated locations for NP_001185938.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK033540, AK150183, DV648268
    Consensus CDS
    CCDS27115.1
    UniProtKB/Swiss-Prot
    Q8JZV8, Q91VU6
    UniProtKB/TrEMBL
    Q3UD98
    Related
    ENSMUSP00000072344.5, ENSMUST00000072530.11
    Conserved Domains (2) summary
    sd00039
    Location:221263
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:171511
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_133734.3NP_598495.1  DDB1- and CUL4-associated factor 11

    See identical proteins and their annotated locations for NP_598495.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK033540, BB845333
    Consensus CDS
    CCDS27115.1
    UniProtKB/Swiss-Prot
    Q8JZV8, Q91VU6
    Related
    ENSMUSP00000113014.2, ENSMUST00000117236.8
    Conserved Domains (2) summary
    sd00039
    Location:221263
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:171511
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_037572.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple splice site differences at the 5' end, compared to variant 1, which result in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record, however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK158784, BB845333
    Related
    ENSMUST00000150019.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55796557..55807522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247848.2XP_030103708.1  DDB1- and CUL4-associated factor 11 isoform X1

    UniProtKB/Swiss-Prot
    Q8JZV8
    Conserved Domains (2) summary
    sd00039
    Location:221263
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:171511
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_030247846.2XP_030103706.1  DDB1- and CUL4-associated factor 11 isoform X1

    UniProtKB/Swiss-Prot
    Q8JZV8
    Conserved Domains (2) summary
    sd00039
    Location:221263
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:171511
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_030247849.2XP_030103709.1  DDB1- and CUL4-associated factor 11 isoform X2

    UniProtKB/TrEMBL
    Q3TYA0
    Conserved Domains (2) summary
    sd00039
    Location:177219
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:136467
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_006519081.5XP_006519144.1  DDB1- and CUL4-associated factor 11 isoform X1

    See identical proteins and their annotated locations for XP_006519144.1

    UniProtKB/Swiss-Prot
    Q8JZV8, Q91VU6
    Conserved Domains (2) summary
    sd00039
    Location:221263
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:171511
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_006519087.5XP_006519150.1  DDB1- and CUL4-associated factor 11 isoform X2

    See identical proteins and their annotated locations for XP_006519150.1

    UniProtKB/Swiss-Prot
    Q91VU6
    UniProtKB/TrEMBL
    Q3TYA0
    Conserved Domains (2) summary
    sd00039
    Location:177219
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:136467
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_030247847.2XP_030103707.1  DDB1- and CUL4-associated factor 11 isoform X1

    UniProtKB/Swiss-Prot
    Q8JZV8
    Conserved Domains (2) summary
    sd00039
    Location:221263
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:171511
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. XM_006519083.5XP_006519146.1  DDB1- and CUL4-associated factor 11 isoform X1

    See identical proteins and their annotated locations for XP_006519146.1

    UniProtKB/Swiss-Prot
    Q8JZV8, Q91VU6
    Conserved Domains (2) summary
    sd00039
    Location:221263
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:171511
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. XM_006519088.5XP_006519151.1  DDB1- and CUL4-associated factor 11 isoform X2

    See identical proteins and their annotated locations for XP_006519151.1

    UniProtKB/Swiss-Prot
    Q91VU6
    UniProtKB/TrEMBL
    Q3TYA0
    Conserved Domains (2) summary
    sd00039
    Location:177219
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:136467
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  9. XM_006519085.5XP_006519148.1  DDB1- and CUL4-associated factor 11 isoform X1

    See identical proteins and their annotated locations for XP_006519148.1

    UniProtKB/Swiss-Prot
    Q8JZV8, Q91VU6
    Related
    ENSMUSP00000113202.2, ENSMUST00000121622.8
    Conserved Domains (2) summary
    sd00039
    Location:221263
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:171511
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  10. XM_006519090.5XP_006519153.1  DDB1- and CUL4-associated factor 11 isoform X2

    See identical proteins and their annotated locations for XP_006519153.1

    UniProtKB/Swiss-Prot
    Q91VU6
    UniProtKB/TrEMBL
    Q3TYA0
    Conserved Domains (2) summary
    sd00039
    Location:177219
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:136467
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  11. XM_006519084.5XP_006519147.1  DDB1- and CUL4-associated factor 11 isoform X1

    See identical proteins and their annotated locations for XP_006519147.1

    UniProtKB/Swiss-Prot
    Q8JZV8, Q91VU6
    Conserved Domains (2) summary
    sd00039
    Location:221263
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:171511
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  12. XM_006519091.5XP_006519154.1  DDB1- and CUL4-associated factor 11 isoform X2

    See identical proteins and their annotated locations for XP_006519154.1

    UniProtKB/Swiss-Prot
    Q91VU6
    UniProtKB/TrEMBL
    Q3TYA0
    Conserved Domains (2) summary
    sd00039
    Location:177219
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:136467
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  13. XM_030247851.2XP_030103711.1  DDB1- and CUL4-associated factor 11 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:5693
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:55299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  14. XM_036158655.1XP_036014548.1  DDB1- and CUL4-associated factor 11 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:5693
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:55299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  15. XM_036158656.1XP_036014549.1  DDB1- and CUL4-associated factor 11 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:5693
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:55299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  16. XM_036158658.1XP_036014551.1  DDB1- and CUL4-associated factor 11 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:5693
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:55299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  17. XM_036158657.1XP_036014550.1  DDB1- and CUL4-associated factor 11 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:5693
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:55299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  18. XM_006519086.5XP_006519149.1  DDB1- and CUL4-associated factor 11 isoform X1

    See identical proteins and their annotated locations for XP_006519149.1

    UniProtKB/Swiss-Prot
    Q8JZV8, Q91VU6
    Conserved Domains (2) summary
    sd00039
    Location:221263
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:171511
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  19. XM_030247850.2XP_030103710.1  DDB1- and CUL4-associated factor 11 isoform X2

    UniProtKB/TrEMBL
    Q3TYA0
    Conserved Domains (2) summary
    sd00039
    Location:177219
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:136467
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  20. XM_036158659.1XP_036014552.1  DDB1- and CUL4-associated factor 11 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:5693
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:55299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...