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PLCG1 phospholipase C gamma 1 [ Bos taurus (domestic cattle) ]

Gene ID: 281987, updated on 5-Sep-2025
Official Symbol
PLCG1provided by VGNC
Official Full Name
phospholipase C gamma 1provided by VGNC
Primary source
VGNC:VGNC:32988
See related
BGD:BT10117; EnsemblRapid:ENSBTAG00070033685
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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See PLCG1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (69790995..69822905)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase I Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC132346963 Neighboring gene U6 spliceosomal RNA Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene receptor-binding cancer antigen expressed on SiSo cells-like

Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells. Wahl MI, et al. J Biol Chem, 1990 Mar 5. PMID 1689311
  2. PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254. Kim HK, et al. Cell, 1991 May 3. PMID 1708307
  3. Intramolecular regulation of phospholipase C-gamma1 by its C-terminal Src homology 2 domain. DeBell K, et al. Mol Cell Biol, 2007 Feb. PMID 17116690, Free PMC Article
  4. A new tyrosine phosphorylation site in PLC gamma 1: the role of tyrosine 775 in immune receptor signaling. Serrano CJ, et al. J Immunol, 2005 May 15. PMID 15879121
  5. The tyrosine [correction of tryrosine] phosphorylation and cytoskeletal translocation of phospholipase C gamma 1 in bovine adrenal medullary chromaffin cells. Roberts-Thomson EL, et al. Neurochem Res, 2004 Oct. PMID 15532540

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PLC-gamma1 is regulated via a novel autoinhibitory mechanism involving its carboxy-terminal Src homology (SH2C) domain.
    Title: Intramolecular regulation of phospholipase C-gamma1 by its C-terminal Src homology 2 domain.
  2. Tyrosine775 is identified as a new, functionally important phosphorylation site on PLC gamma 1; phosphorylation of both Y775 and Y783 is required for PLC gamma 1 activation as measured by antigen receptor-induced Ca2+ flux, NF-AT and AP-1 activation.
    Title: A new tyrosine phosphorylation site in PLC gamma 1: the role of tyrosine 775 in immune receptor signaling.
  3. This study is the first to indicate that PLC gamma 1 is expressed in bovine adrenal chromaffin cells and has the potential to be activated.
    Title: The tyrosine [correction of tryrosine] phosphorylation and cytoskeletal translocation of phospholipase C gamma 1 in bovine adrenal medullary chromaffin cells.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Names
PLC-148
PLC-II
PLC-gamma-1
phosphoinositide phospholipase C
phosphoinositide phospholipase C-gamma-1
phospholipase C-II
NP_776850.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174425.3 → NP_776850.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

    See identical proteins and their annotated locations for NP_776850.1

    Status: PROVISIONAL

    Source sequence(s)
    Y00301
    UniProtKB/Swiss-Prot
    P08487
    UniProtKB/TrEMBL
    A0AAA9T7A8
    Related
    ENSBTAP00070046310.1, ENSBTAT00070075954.1
    Conserved Domains (10) summary
    smart00149
    Location:954 → 1069
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1087 → 1211
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:319 → 466
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:663 → 765
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:545 → 649
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:791 → 850
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:864 → 933
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:29 → 151
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    pfam00169
    Location:71 → 142
    PH; PH domain
    cl17171
    Location:489 → 523
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    69790995..69822905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08487.1 GenPept UniProtKB/Swiss-Prot:P08487

Gene LinkOut

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Molecular Biology Databases
Research Materials