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PDE6A phosphodiesterase 6A [ Bos taurus (domestic cattle) ]

Gene ID: 281973, updated on 5-Sep-2025
Official Symbol
PDE6Aprovided by VGNC
Official Full Name
phosphodiesterase 6Aprovided by VGNC
Primary source
VGNC:VGNC:32679
See related
BGD:BT28333; EnsemblRapid:ENSBTAG00070004401
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
all
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Try the new Transcripts and proteins table
See PDE6A in Genome Data Viewer
Location:
chromosome: 7
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (61195051..61318891, complement)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 37 Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene PPARG coactivator 1 beta Neighboring gene microRNA mir-378-1 Neighboring gene uncharacterized LOC132345770 Neighboring gene solute carrier family 26 member 2 Neighboring gene HMG-box containing 3 Neighboring gene colony stimulating factor 1 receptor

Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. [Cyclic GMP phosphodiesterase from the bovine retina. Amino acid sequence of the alpha-subunit and nucleotide sequence of corresponding cDNA]. Ovchinnikov IuA, et al. Dokl Akad Nauk SSSR, 1987. PMID 2826095
  2. Cyclic GMP phosphodiesterase from bovine retina. Amino acid sequence of the alpha-subunit and nucleotide sequence of the corresponding cDNA. Ovchinnikov YuA, et al. FEBS Lett, 1987 Oct 19. PMID 2822478
  3. Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene. Pittler SJ, et al. Genomics, 1990 Feb. PMID 2155175
  4. Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6. Gao Y, et al. Mol Cell, 2020 Oct 15. PMID 33007200, Free PMC Article
  5. The molecular architecture of photoreceptor phosphodiesterase 6 (PDE6) with activated G protein elucidates the mechanism of visual excitation. Irwin MJ, et al. J Biol Chem, 2019 Dec 20. PMID 31690623, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6.
    Title: Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6.
  2. Analysis of the Rod PDE6 holoenzyme (subunit composition, alphabetagammagamma) reveals the mechanism of visual excitation
    Title: The molecular architecture of photoreceptor phosphodiesterase 6 (PDE6) with activated G protein elucidates the mechanism of visual excitation.
  3. a structural basis for interpreting how mutations in rod PDE6 subunits can lead to retinal diseases, is discussed.
    Title: Allosteric Regulation of Rod Photoreceptor Phosphodiesterase 6 (PDE6) Elucidated by Chemical Cross-Linking and Quantitative Mass Spectrometry.
  4. The approximately 11 A map revealed previously unseen features of PDE6, and each domain was readily fit with high resolution structures.
    Title: Domain organization and conformational plasticity of the G protein effector, PDE6.
  5. although Pgamma-mediated regulation plays the dominant role in visual excitation, the direct, inter-domain allosteric regulation may play a feedback role in light adaptational processes during phototransduction
    Title: Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.
  6. Structural analysis of cGMP phosphodiesterase 6 alpha, beta and gamma interactions
    Title: Three-dimensional structure of non-activated cGMP phosphodiesterase 6 and comparison of its image with those of activated forms.
  7. the unique Palphabeta heterodimer contributes to the sophisticated regulation in visual transduction through interaction with Pgamma
    Title: Asymmetric interaction between rod cyclic GMP phosphodiesterase gamma subunits and alphabeta subunits.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in retina development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in photoreceptor outer segment membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Names
GMP-PDE alpha
PDE V-B1
phosphodiesterase 6A, cGMP-specific, rod, alpha
phosphodiesterase, cyclic GMP (rod receptor), alpha polypeptide
NP_001001526.2
XP_024849609.1
XP_059743916.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001526.2 → NP_001001526.2  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

    See identical proteins and their annotated locations for NP_001001526.2

    Status: PROVISIONAL

    Source sequence(s)
    X12756
    UniProtKB/TrEMBL
    E1BK80
    Related
    ENSBTAP00070005767.1, ENSBTAT00070010024.1
    Conserved Domains (2) summary
    smart00065
    Location:254 → 441
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:558 → 802
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    61195051..61318891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024993841.2 → XP_024849609.1  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1

    Conserved Domains (3) summary
    smart00065
    Location:72 → 259
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:376 → 617
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    cl21515
    Location:1 → 50
    GAF; GAF domain

  2. XM_059887933.1 → XP_059743916.1  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11541.3 GenPept UniProtKB/Swiss-Prot:P11541

Gene LinkOut

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Molecular Biology Databases
Research Materials