U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NT5C2 5'-nucleotidase, cytosolic II [ Bos taurus (domestic cattle) ]

Gene ID: 281951, updated on 5-Sep-2025
Official Symbol
NT5C2provided by VGNC
Official Full Name
5'-nucleotidase, cytosolic IIprovided by VGNC
Primary source
VGNC:VGNC:32291
See related
BGD:BT21549; EnsemblRapid:ENSBTAG00070010492
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See NT5C2 in Genome Data Viewer
Location:
chromosome: 26
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 26 NC_037353.1 (23739167..23836661, complement)

Chromosome 26 - NC_037353.1Genomic Context describing neighboring genes Neighboring gene BLOC-1 related complex subunit 7 Neighboring gene arsenite methyltransferase Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 2 Neighboring gene ubiquitin-ribosomal protein eS31 fusion protein-like Neighboring gene chromosome 26 C6orf52 homolog Neighboring gene internexin neuronal intermediate filament protein alpha Neighboring gene polycomb group ring finger 6

Genomic Sequence:
NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Cytosolic 5'-Nucleotidase II Is a Sensor of Energy Charge and Oxidative Stress: A Possible Function as Metabolic Regulator. Pesi R, et al. Cells, 2021 Jan 18. PMID 33477638, Free PMC Article
  2. Active and regulatory sites of cytosolic 5'-nucleotidase. Pesi R, et al. FEBS J, 2010 Dec. PMID 21029378
  3. Bovine cytosolic IMP/GMP-specific 5'-nucleotidase: cloning and expression of active enzyme in Escherichia coli. Allegrini S, et al. Biochem J, 1997 Dec 1. PMID 9371705, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 5'-nucleotidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in IMP metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adenosine metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
cytosolic purine 5'-nucleotidase
Names
cytosolic 5'-nucleotidase II
cytosolic IMP/GMP-specific 5'-nucleotidase
cytosolic nucleoside phosphotransferase 5'N
NP_776830.1
XP_005225489.1
XP_005225491.1
XP_059737708.1
XP_059737709.1
XP_059737710.1
XP_059737711.1
XP_059737712.1
XP_059737713.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174405.2 → NP_776830.1  cytosolic purine 5'-nucleotidase

    See identical proteins and their annotated locations for NP_776830.1

    Status: PROVISIONAL

    Source sequence(s)
    U73690
    UniProtKB/Swiss-Prot
    O46411
    UniProtKB/TrEMBL
    A0A3Q1MSX0, B1H0W4
    Related
    ENSBTAP00070013903.1, ENSBTAT00070023519.1
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 488
    5_nucleotid; 5' nucleotidase family

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037353.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    23739167..23836661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005225434.5 → XP_005225491.1  cytosolic purine 5'-nucleotidase isoform X3

    See identical proteins and their annotated locations for XP_005225491.1

    UniProtKB/Swiss-Prot
    O46411
    UniProtKB/TrEMBL
    A0A3Q1MSX0, B1H0W4
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 488
    5_nucleotid; 5' nucleotidase family

  2. XM_005225432.5 → XP_005225489.1  cytosolic purine 5'-nucleotidase isoform X1

    See identical proteins and their annotated locations for XP_005225489.1

    UniProtKB/TrEMBL
    A0A3Q1MSX0, A0AAF7AMR3
    Related
    ENSBTAP00070013891.1, ENSBTAT00070023504.1
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 496
    5_nucleotid; 5' nucleotidase family

  3. XM_059881725.1 → XP_059737708.1  cytosolic purine 5'-nucleotidase isoform X2

    UniProtKB/TrEMBL
    A0A452DIK1
    Related
    ENSBTAP00070013876.1, ENSBTAT00070023483.1

  4. XM_059881726.1 → XP_059737709.1  cytosolic purine 5'-nucleotidase isoform X4

    UniProtKB/TrEMBL
    A0A3Q1MUV3
    Related
    ENSBTAP00070013866.1, ENSBTAT00070023472.1

  5. XM_059881727.1 → XP_059737710.1  cytosolic purine 5'-nucleotidase isoform X5

    UniProtKB/TrEMBL
    A0A3Q1ML41
    Related
    ENSBTAP00070013860.1, ENSBTAT00070023463.1

  6. XM_059881730.1 → XP_059737713.1  cytosolic purine 5'-nucleotidase isoform X6

  7. XM_059881728.1 → XP_059737711.1  cytosolic purine 5'-nucleotidase isoform X6

  8. XM_059881729.1 → XP_059737712.1  cytosolic purine 5'-nucleotidase isoform X6

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O46411.1 GenPept UniProtKB/Swiss-Prot:O46411

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.