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NR3C1 nuclear receptor subfamily 3 group C member 1 [ Bos taurus (domestic cattle) ]

Gene ID: 281946, updated on 19-Feb-2025
Official Symbol
NR3C1provided by VGNC
Official Full Name
nuclear receptor subfamily 3 group C member 1provided by VGNC
Primary source
VGNC:VGNC:32243
See related
BGD:BT11806; EnsemblRapid:ENSBTAG00070031508
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
GR-A
Orthologs
human mouse all
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See NR3C1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (54344785..54491820, complement)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100847454 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene fibroblast growth factor 1 Neighboring gene Rho GTPase activating protein 26 Neighboring gene uncharacterized LOC132345824 Neighboring gene uncharacterized LOC107132646 Neighboring gene heterogeneous nuclear ribonucleoproteins A2/B1-like Neighboring gene Yip1 domain family member 5

Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Association of glucocorticoid receptor expression with key members of the insulin signaling pathway and heat shock proteins in the bovine ovary. Rodríguez FM, et al. Theriogenology, 2023 Nov. PMID 37677868
  2. Role of Glucocorticoids in Cystic Ovarian Disease: Expression of Glucocorticoid Receptor in the Bovine Ovary. Amweg AN, et al. Cells Tissues Organs, 2016. PMID 26677854
  3. Specificity protein 1 (Sp1) and glucocorticoid receptor (GR) stimulate bovine alphaherpesvirus 1 (BoHV-1) replication and cooperatively transactivate the immediate early transcription unit 1 promoter. El-Mayet FS, et al. J Virol, 2024 Jan 23. PMID 38084958, Free PMC Article
  4. Bayesian image analysis of dexamethasone and shear stress-induced glucocorticoid receptor intracellular movement. Nayebosadri A, et al. Ann Biomed Eng, 2012 Jul. PMID 22227972
  5. Presence of a transcriptionally active glucocorticoid receptor alpha in lens epithelial cells. James ER, et al. Invest Ophthalmol Vis Sci, 2003 Dec. PMID 14638726

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Specificity protein 1 (Sp1) and glucocorticoid receptor (GR) stimulate bovine alphaherpesvirus 1 (BoHV-1) replication and cooperatively transactivate the immediate early transcription unit 1 promoter.
    Title: Specificity protein 1 (Sp1) and glucocorticoid receptor (GR) stimulate bovine alphaherpesvirus 1 (BoHV-1) replication and cooperatively transactivate the immediate early transcription unit 1 promoter.
  2. Association of glucocorticoid receptor expression with key members of the insulin signaling pathway and heat shock proteins in the bovine ovary.
    Title: Association of glucocorticoid receptor expression with key members of the insulin signaling pathway and heat shock proteins in the bovine ovary.
  3. Glucocorticoid Receptor protein expression in granulosa cells was higher in cysts from animals with spontaneous cystic ovarian disease and adrenocorticotropic hormone-induced cystic ovarian disease than in tertiary follicles from control animals.
    Title: Role of Glucocorticoids in Cystic Ovarian Disease: Expression of Glucocorticoid Receptor in the Bovine Ovary.
  4. Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected.
    Title: Altered expression of inflammation-associated genes in oviductal cells following follicular fluid exposure: implications for ovarian carcinogenesis.
  5. Bayesian image analysis of dexamethasone and shear stress-induced glucocorticoid receptor intracellular movement
    Title: Bayesian image analysis of dexamethasone and shear stress-induced glucocorticoid receptor intracellular movement.
  6. investigation of gene expression for GR, 11HSD1, and 11HSD2 in granulosa cells and theca interna layers during follicular maturation and atresia: expression of GR was largely unchanged during follicular maturation
    Title: Gene expression of 11β-HSD and glucocorticoid receptor in the bovine (Bos taurus) follicle during follicular maturation and atresia: the role of follicular stimulating hormone.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables estrogen response element binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear glucocorticoid receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in nuclear receptor-mediated glucocorticoid signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
glucocorticoid receptor
Names
glucocorticoid receptor alpha
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206634.1 → NP_001193563.1  glucocorticoid receptor

    See identical proteins and their annotated locations for NP_001193563.1

    Status: VALIDATED

    Source sequence(s)
    NKLS02000007
    UniProtKB/TrEMBL
    F1MN19
    Conserved Domains (3) summary
    cd07076
    Location:535 → 781
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:421 → 498
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27 → 406
    GCR; Glucocorticoid receptor

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    54344785..54491820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024993837.2 → XP_024849605.1  glucocorticoid receptor isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M7I4, F1MN19
    Conserved Domains (3) summary
    cd07076
    Location:536 → 782
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:421 → 499
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27 → 406
    GCR; Glucocorticoid receptor

  2. XM_059887929.1 → XP_059743912.1  glucocorticoid receptor isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M7I4, F1MN19

  3. XM_024993840.2 → XP_024849608.1  glucocorticoid receptor isoform X2

    UniProtKB/TrEMBL
    F1MN19
    Conserved Domains (3) summary
    cd07076
    Location:535 → 781
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:421 → 498
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27 → 406
    GCR; Glucocorticoid receptor

  4. XM_005209530.5 → XP_005209587.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_005209587.1

    UniProtKB/TrEMBL
    A0A3Q1M7I4, F1MN19
    Conserved Domains (3) summary
    cd07076
    Location:536 → 782
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:421 → 499
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27 → 406
    GCR; Glucocorticoid receptor

  5. XM_024993839.2 → XP_024849607.1  glucocorticoid receptor isoform X2

    UniProtKB/TrEMBL
    F1MN19
    Related
    ENSBTAP00070043530.1, ENSBTAT00070071320.1
    Conserved Domains (3) summary
    cd07076
    Location:535 → 781
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:421 → 498
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27 → 406
    GCR; Glucocorticoid receptor

  6. XM_005209529.5 → XP_005209586.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_005209586.1

    UniProtKB/TrEMBL
    A0A3Q1M7I4, F1MN19
    Conserved Domains (3) summary
    cd07076
    Location:536 → 782
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:421 → 499
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27 → 406
    GCR; Glucocorticoid receptor

  7. XM_059887931.1 → XP_059743914.1  glucocorticoid receptor isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M7I4, F1MN19

  8. XM_005209528.5 → XP_005209585.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_005209585.1

    UniProtKB/TrEMBL
    A0A3Q1M7I4, F1MN19
    Related
    ENSBTAP00070043552.1, ENSBTAT00070071358.1
    Conserved Domains (3) summary
    cd07076
    Location:536 → 782
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:421 → 499
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27 → 406
    GCR; Glucocorticoid receptor

  9. XM_005209531.4 → XP_005209588.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_005209588.1

    UniProtKB/TrEMBL
    A0A3Q1M7I4, F1MN19
    Conserved Domains (3) summary
    cd07076
    Location:536 → 782
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:421 → 499
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27 → 406
    GCR; Glucocorticoid receptor

  10. XM_059887932.1 → XP_059743915.1  glucocorticoid receptor isoform X3

    UniProtKB/TrEMBL
    F1MN19

RNA

  1. XR_009495049.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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