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MOCS1 molybdenum cofactor synthesis 1 [ Bos taurus (domestic cattle) ]

Gene ID: 281917, updated on 12-Oct-2024

Summary

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Official Symbol
MOCS1provided by VGNC
Official Full Name
molybdenum cofactor synthesis 1provided by VGNC
Primary source
VGNC:VGNC:54229
See related
BGD:BT29886; Ensembl:ENSBTAG00000010449
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See MOCS1 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (13836251..13870753, complement)

Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene transcription initiation factor TFIID subunit 9-like Neighboring gene dishevelled associated activator of morphogenesis 2 Neighboring gene U6 spliceosomal RNA Neighboring gene large ribosomal subunit protein eL42-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Diverse splicing mechanisms fuse the evolutionarily conserved bicistronic MOCS1A and MOCS1B open reading frames. Gray TA, et al. RNA, 2000 Jul. PMID 10917590, Free PMC Article
  2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTP 3',8'-cyclase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cyclic pyranopterin monophosphate synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
molybdenum cofactor biosynthesis protein 1
NP_001013615.1
NP_001159769.1
XP_005223423.1
XP_024839148.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013597.1 → NP_001013615.1  molybdenum cofactor biosynthesis protein 1 isoform b

    See identical proteins and their annotated locations for NP_001013615.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (b) represents use of an alternate splice site resulting in a truncated 3' coding region, compared to variant a. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    BT021581
    UniProtKB/Swiss-Prot
    Q1JQD7
    Conserved Domains (3) summary
    cd01335
    Location:71 → 269
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    PLN02951
    Location:30 → 382
    PLN02951; Molybderin biosynthesis protein CNX2
    pfam06463
    Location:238 → 364
    Mob_synth_C; Molybdenum Cofactor Synthesis C

  2. NM_001166297.1 → NP_001159769.1  molybdenum cofactor biosynthesis protein 1 isoform a

    See identical proteins and their annotated locations for NP_001159769.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (a) represents the shorter transcript but encodes the longer isoform (a).
    Source sequence(s)
    BC116030, BC126847
    UniProtKB/Swiss-Prot
    A8SMN8, Q1JQD7, Q58DL6
    UniProtKB/TrEMBL
    A0A3Q1LLZ9
    Related
    ENSBTAP00000057654.2, ENSBTAT00000084036.2
    Conserved Domains (2) summary
    PLN02951
    Location:30 → 380
    PLN02951; Molybderin biosynthesis protein CNX2
    PRK09364
    Location:476 → 633
    moaC; cyclic pyranopterin monophosphate synthase MoaC

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    13836251..13870753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005223366.5 → XP_005223423.1  molybdenum cofactor biosynthesis protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LLZ9, A0AAF6YV68
    Related
    ENSBTAP00000013792.6, ENSBTAT00000013792.7
    Conserved Domains (4) summary
    cd01335
    Location:71 → 269
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    PRK00164
    Location:51 → 375
    moaA; molybdenum cofactor biosynthesis protein A; Reviewed
    PRK09364
    Location:460 → 617
    moaC; molybdenum cofactor biosynthesis protein MoaC; Provisional
    pfam06463
    Location:238 → 364
    Mob_synth_C; Molybdenum Cofactor Synthesis C

  2. XM_024983380.2 → XP_024839148.1  molybdenum cofactor biosynthesis protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A3Q1LLZ9
    Conserved Domains (2) summary
    PRK09364
    Location:392 → 549
    moaC; molybdenum cofactor biosynthesis protein MoaC; Provisional
    cl28177
    Location:1 → 296
    SkfB; Radical SAM superfamily enzyme, MoaA/NifB/PqqE/SkfB family [General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1JQD7.2 GenPept UniProtKB/Swiss-Prot:Q1JQD7

Gene LinkOut

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