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LHCGR luteinizing hormone/choriogonadotropin receptor [ Bos taurus (domestic cattle) ]

Gene ID: 281900, updated on 5-Sep-2025
Gene symbol
LHCGR
Gene description
luteinizing hormone/choriogonadotropin receptor
See related
BGD:BT10044; EnsemblRapid:ENSBTAG00070005983
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See LHCGR in Genome Data Viewer
Location:
chromosome: 11
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (30974912..31040366, complement)

Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene stonin 1 Neighboring gene general transcription factor IIA subunit 1 like Neighboring gene uncharacterized LOC132346571 Neighboring gene follicle stimulating hormone receptor Neighboring gene uncharacterized LOC132346572

Genomic Sequence:
NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Influence of FSH and hCG on the resumption of meiosis of bovine oocytes surrounded by cumulus cells connected to membrana granulosa. van Tol HT, et al. Mol Reprod Dev, 1996 Oct. PMID 8914080
  2. LH receptor mRNA and cytochrome P450 side-chain cleavage expression in bovine theca and granulosa cells luteinized by LH or forskolin. Mamluk R, et al. Domest Anim Endocrinol, 1998 Mar. PMID 9532424
  3. Pre-translational regulation of luteinizing hormone receptor in follicular somatic cells of cattle. Marsters P, et al. Anim Reprod Sci, 2015 Dec. PMID 26507944, Free PMC Article
  4. Polymorphisms within the coding region of the bovine luteinizing hormone receptor gene and their association with fertility traits. Hastings N, et al. Anim Genet, 2006 Dec. PMID 17121604
  5. Expression of LH receptor mRNA splice variants in bovine granulosa cells: changes with follicle size and regulation by FSH in vitro. Nogueira MF, et al. Mol Reprod Dev, 2007 Jun. PMID 17154302

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. large numbers of unknown LH-regulated granulosa cell genes are identified and their putative roles in ovarian function, are reported.
    Title: Research resource: preovulatory LH surge effects on follicular theca and granulosa transcriptomes.
  2. Gene expression of granulosa cells reveals that 747 transcripts are potentially regulated by LH.
    Title: Influence of luteinizing hormone support on granulosa cells transcriptome in cattle.
  3. The outcomes of the present study support a dynamic multi-facetted regulation of LHR during pre-translation.
    Title: Pre-translational regulation of luteinizing hormone receptor in follicular somatic cells of cattle.
  4. expression of LHR mRNA in bovine granulosa cells is established after follicle deviation, and the lower abundance of LRBP mRNA after the expected time of deviation may contribute to greater expression of LHR in the bovine dominant follicle
    Title: Expression of mRNA Encoding the LH Receptor (LHR) and LHR Binding Protein in Granulosa Cells from Nelore (Bos indicus) Heifers Around Follicle Deviation.
  5. These results suggested an acute regulation of INSL3 by luteinizing hormone (LH) because INSL3 concentrations increased immediately after endogenous and exogenous LH stimulation.
    Title: Plasma insulin-like peptide 3 concentrations are acutely regulated by luteinizing hormone in pubertal Japanese Black beef bulls.
  6. INVESTIGATION OF STAT5A, FSHR AND LHR GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS
    Title: INVESTIGATION OF STAT5A, FSHR AND LHR GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS (EAST ANATOLLAN RED, SOUTH ANATOLIAN RED, TURKISH GREY, ANATOLIAN BLACK AND ZAVOT).
  7. These findings strongly support the concept that IGF-1 upregulates LHR expression in granulosa cells and that IGF-1 is required for determining which follicle becomes dominant and acquires ovulatory capacity.
    Title: Insulin-like growth factor-1 regulates the expression of luteinizing hormone receptor and steroid production in bovine granulosa cells.
  8. LHCGR mRNA expression in granulosa cells was significantly higher in large antral follicles than in cysts, and not detected in granulosa cells of small and medium antral follicles.
    Title: mRNA expression pattern of gonadotropin receptors in bovine follicular cysts.
  9. The luteinizing hormone receptor [LHR] splicing pattern is complex in bovine Leydig cells, and expression of full-length LHR and isoforms A and B changes when induced with LH.
    Title: Luteinizing hormone receptor splicing variants in bovine Leydig cells.
  10. Significant correlations were found between sperm quality parameters and polymorphisms in the luteinizing hromoe receptor gene in Chinese Holstein bulls.
    Title: Polymorphisms in luteinizing hormone receptor and hypothalamic gonadotropin-releasing hormone genes and their effects on sperm quality traits in Chinese Holstein bulls.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables luteinizing hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in luteinizing hormone signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in male gonad development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ovarian follicle development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ovulation cycle process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
lutropin-choriogonadotropic hormone receptor
Names
LH/CG-R
LSH-R
luteinizing hormone receptor 2 protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174381.1 → NP_776806.1  lutropin-choriogonadotropic hormone receptor precursor

    See identical proteins and their annotated locations for NP_776806.1

    Status: PROVISIONAL

    Source sequence(s)
    U20504
    UniProtKB/Swiss-Prot
    P79133, Q28005, Q8SPS8
    UniProtKB/TrEMBL
    A0A140T893
    Related
    ENSBTAP00070007956.1, ENSBTAT00070013703.1
    Conserved Domains (3) summary
    sd00033
    Location:53 → 76
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00001
    Location:378 → 625
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam13306
    Location:64 → 202
    LRR_5; Leucine rich repeats (6 copies)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    30974912..31040366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024998286.2 → XP_024854054.1  lutropin-choriogonadotropic hormone receptor isoform X3

    UniProtKB/TrEMBL
    A0A140T893
    Conserved Domains (3) summary
    sd00031
    Location:53 → 76
    LRR_1; leucine-rich repeat [structural motif]
    cd15359
    Location:286 → 560
    7tmA_LHCGR; luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl26222
    Location:64 → 158
    LRR_5; Leucine rich repeats (6 copies)

  2. XM_010809898.4 → XP_010808200.1  lutropin-choriogonadotropic hormone receptor isoform X1

    UniProtKB/TrEMBL
    A0A140T893
    Conserved Domains (3) summary
    sd00033
    Location:53 → 76
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00001
    Location:353 → 600
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam13306
    Location:64 → 197
    LRR_5; Leucine rich repeats (6 copies)

  3. XM_005212546.5 → XP_005212603.1  lutropin-choriogonadotropic hormone receptor isoform X2

    UniProtKB/TrEMBL
    A0A140T893, A0A3Q1MTR7
    Related
    ENSBTAP00070007978.1, ENSBTAT00070013730.1
    Conserved Domains (3) summary
    sd00033
    Location:53 → 76
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00001
    Location:351 → 598
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam13306
    Location:64 → 202
    LRR_5; Leucine rich repeats (6 copies)

  4. XM_059891005.1 → XP_059746988.1  lutropin-choriogonadotropic hormone receptor isoform X6

  5. XM_015473420.3 → XP_015328906.1  lutropin-choriogonadotropic hormone receptor isoform X4

    Conserved Domains (2) summary
    sd00033
    Location:53 → 76
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13306
    Location:64 → 202
    LRR_5; Leucine rich repeats (6 copies)

  6. XM_015473421.3 → XP_015328907.1  lutropin-choriogonadotropic hormone receptor isoform X5

    Conserved Domains (2) summary
    sd00033
    Location:53 → 76
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13306
    Location:64 → 202
    LRR_5; Leucine rich repeats (6 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28005.1 GenPept UniProtKB/Swiss-Prot:Q28005

Gene LinkOut

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Molecular Biology Databases
Research Materials