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INHBA inhibin subunit beta A [ Bos taurus (domestic cattle) ]

Gene ID: 281867, updated on 5-Sep-2025
Official Symbol
INHBAprovided by VGNC
Official Full Name
inhibin subunit beta Aprovided by VGNC
Primary source
VGNC:VGNC:30200
See related
BGD:BT10605; EnsemblRapid:ENSBTAG00070016353
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See INHBA in Genome Data Viewer
Location:
chromosome: 4
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (79279914..79304488)

Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene nucleosome assembly protein 1-like 1 Neighboring gene translation initiation factor IF-2 Neighboring gene GLI family zinc finger 3 Neighboring gene microRNA mir-11996 Neighboring gene succinyl-CoA:glutarate-CoA transferase Neighboring gene uncharacterized LOC112446478 Neighboring gene uncharacterized LOC132345172

Genomic Sequence:
NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Changes in expression of bone morphogenetic proteins (BMPs), their receptors and inhibin co-receptor betaglycan during bovine antral follicle development: inhibin can antagonize the suppressive effect of BMPs on thecal androgen production. Glister C, et al. Reproduction, 2010 Nov. PMID 20739376
  2. Purification and characterization of high molecular weight forms of inhibin from bovine follicular fluid. Sugino K, et al. Endocrinology, 1992 Feb. PMID 1733725
  3. Cloning and sequence analysis of cDNA species coding for the two subunits of inhibin from bovine follicular fluid. Forage RG, et al. Proc Natl Acad Sci U S A, 1986 May. PMID 3458167, Free PMC Article
  4. Actions of activin A, connective tissue growth factor, hepatocyte growth factor and teratocarcinoma-derived growth factor 1 on the development of the bovine preimplantation embryo. Kannampuzha-Francis J, et al. Reprod Fertil Dev, 2017 Jul. PMID 27185102
  5. Role of activin, inhibin, and follistatin in the pathogenesis of bovine cystic ovarian disease. Stangaferro ML, et al. Anim Reprod Sci, 2014 Aug. PMID 25001504

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results confirm the prodevelopmental actions of activin A and indicate that CTGF may also function as an embryokine by regulating the number of ICM cells in the blastocyst and altering gene expression. Low concentrations of HGF were inhibitory to development.
    Title: Actions of activin A, connective tissue growth factor, hepatocyte growth factor and teratocarcinoma-derived growth factor 1 on the development of the bovine preimplantation embryo.
  2. The expression of the components of the activin-inhibin-follistatin system is altered in bovine cystic ovarian disease.
    Title: Role of activin, inhibin, and follistatin in the pathogenesis of bovine cystic ovarian disease.
  3. Results support a physiological role for granulosa-derived inhibin as an antagonist of bone morphogenetic protein action on thecal androgen synthesis.
    Title: Changes in expression of bone morphogenetic proteins (BMPs), their receptors and inhibin co-receptor betaglycan during bovine antral follicle development: inhibin can antagonize the suppressive effect of BMPs on thecal androgen production.
  4. activin AB is a lignd for activin type IB receptor ALK7 and is responsible for activin-mediated secretion of insulin from pancreatic beta cell line, MIN6.
    Title: Activin isoforms signal through type I receptor serine/threonine kinase ALK7.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
inhibin beta A chain
Names
activin beta-A chain
inhibin beta A subunit
inhibin, beta A (activin A, activin AB alpha polypeptide)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174363.2 → NP_776788.1  inhibin beta A chain precursor

    See identical proteins and their annotated locations for NP_776788.1

    Status: PROVISIONAL

    Source sequence(s)
    BC126556
    UniProtKB/Swiss-Prot
    A0JN81, P07995
    Conserved Domains (2) summary
    pfam00688
    Location:56 → 242
    TGFb_propeptide; TGF-beta propeptide
    cd19404
    Location:318 → 425
    TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    79279914..79304488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024990466.2 → XP_024846234.1  inhibin beta A chain isoform X1

    UniProtKB/Swiss-Prot
    A0JN81, P07995
    Related
    ENSBTAP00070021593.1, ENSBTAT00070036721.1
    Conserved Domains (2) summary
    pfam00688
    Location:56 → 242
    TGFb_propeptide; TGF-beta propeptide
    cd19404
    Location:318 → 425
    TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins

  2. XM_005205620.5 → XP_005205677.1  inhibin beta A chain isoform X1

    See identical proteins and their annotated locations for XP_005205677.1

    UniProtKB/Swiss-Prot
    A0JN81, P07995
    Conserved Domains (2) summary
    pfam00688
    Location:56 → 242
    TGFb_propeptide; TGF-beta propeptide
    cd19404
    Location:318 → 425
    TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07995.2 GenPept UniProtKB/Swiss-Prot:P07995

Gene LinkOut

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