IL2RA interleukin 2 receptor subunit alpha [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: IL2RAprovided by VGNC
Official Full Name: interleukin 2 receptor subunit alphaprovided by VGNC
Primary source: VGNC:VGNC:56188
See related: EnsemblRapid:ENSBTAG00070023422
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: CD25
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	13	NC_037340.1 (17455392..17500715)

Chromosome 13 - NC_037340.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential expression of CD25 and IDO mRNA with high and low virulence bovine viral diarrhea virus might reflect temporal differences in transcription during the immune response elicited by these viral strains.
Title: Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves.
Increase of CD25 expression on bovine neutrophils correlates with mastitis severity in post-partum and early lactating dairy cows.
Title: Increase of CD25 expression on bovine neutrophils correlates with disease severity in post-partum and early lactating dairy cows.
The PGE2-mediated down-regulation of CD25 expression on T cells is mediated via the EP4 receptor, although selective activation of the EP2 receptor up-regulates the CD25 expression on these cells.
Title: Prostaglandin E₂ down-regulates the expression of CD25 on bovine T cells, and this effect is mediated through the EP4 receptor.
There is a positive correlation between the intensity of CD25 expression and the expression of the transcription Foxp3 factor in bovine CD8(+) cells.
Title: Foxp3 expression in bovine CD8+ T cells is associated with the intensity of CD25 expression.
These findings revealed that despite the existence of a distinct bovine CD4(+)CD25(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population
Title: Subpopulations of bovine WC1(+) gammadelta T cells rather than CD4(+)CD25(high) Foxp3(+) T cells act as immune regulatory cells ex vivo.
Pretreatment of neonatal PBMC with IL-1beta, TNF-alpha or IFN-gamma promotes mitogenic response to ConA through up-regulating the production of IL-2 and the expression of the mature IL-2 receptor.
Title: Proinflammatory cytokines in bovine colostrum potentiate the mitogenic response of peripheral blood mononuclear cells from newborn calves through IL-2 and CD25 expression.
determined the effects of Mycobacterium-induced proliferation and apoptosis on CD25, CD44, and CD62L expression on peripheral blood T-cell subsets from M. bovis-infected cattle.
Title: Expression of L-Selectin (CD62L), CD44, and CD25 on activated bovine T cells.

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General gene information

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Markers

IL2RA-2 (e-PCR)
- UniSTS:253716

IL2RA (e-PCR), detects polymorphism
- UniSTS:253716

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables interleukin-2 binding	IEA Inferred from Electronic Annotation more info	PubMed
enables interleukin-2 receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-2 receptor subunit alpha

Names: IL-2 receptor alpha subunit; IL-2 receptor subunit alpha; IL-2-RA; IL-2R alpha; IL-2R subunit alpha; IL2-RA; TAC antigen; cytokine receptor; interleukin 2 receptor, alpha; interleukin-2 receptor alpha chain; p55

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174358.3 → NP_776783.2 interleukin-2 receptor subunit alpha precursor

Status: VALIDATED

Source sequence(s)

NKLS02000013

UniProtKB/Swiss-Prot

P12342

UniProtKB/TrEMBL

A2VE30, E1BEN0, F1MUD7

Related

ENSBTAP00070031700.1, ENSBTAT00070052829.1