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IL2RA interleukin 2 receptor subunit alpha [ Bos taurus (domestic cattle) ]

Gene ID: 281861, updated on 17-Aug-2024

Summary

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Official Symbol
IL2RAprovided by VGNC
Official Full Name
interleukin 2 receptor subunit alphaprovided by VGNC
Primary source
VGNC:VGNC:56188
See related
Ensembl:ENSBTAG00000020892
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
CD25
Orthologs
human mouse all
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Genomic context

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See IL2RA in Genome Data Viewer
Location:
chromosome: 13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (17455219..17500715)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112449256 Neighboring gene RNA binding motif protein 17 Neighboring gene interleukin 15 receptor subunit alpha Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene F-box DNA helicase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Increase of CD25 expression on bovine neutrophils correlates with disease severity in post-partum and early lactating dairy cows. Zoldan K, et al. Dev Comp Immunol, 2014 Dec. PMID 25106916
  2. Cloning of cDNA for the bovine IL-2 receptor (bovine Tac antigen). Weinberg AD, et al. Immunology, 1988 Apr. PMID 2835311, Free PMC Article
  3. Prostaglandin E₂ down-regulates the expression of CD25 on bovine T cells, and this effect is mediated through the EP4 receptor. Maślanka T, et al. Vet Immunol Immunopathol, 2014 Aug 15. PMID 25001909
  4. Foxp3 expression in bovine CD8+ T cells is associated with the intensity of CD25 expression. Maślanka T, et al. J Vet Med Sci, 2013 Feb. PMID 23059841
  5. Proinflammatory cytokines in bovine colostrum potentiate the mitogenic response of peripheral blood mononuclear cells from newborn calves through IL-2 and CD25 expression. Yamanaka H, et al. Microbiol Immunol, 2003. PMID 12906107

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differential expression of CD25 and IDO mRNA with high and low virulence bovine viral diarrhea virus might reflect temporal differences in transcription during the immune response elicited by these viral strains.
    Title: Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves.
  2. Increase of CD25 expression on bovine neutrophils correlates with mastitis severity in post-partum and early lactating dairy cows.
    Title: Increase of CD25 expression on bovine neutrophils correlates with disease severity in post-partum and early lactating dairy cows.
  3. The PGE2-mediated down-regulation of CD25 expression on T cells is mediated via the EP4 receptor, although selective activation of the EP2 receptor up-regulates the CD25 expression on these cells.
    Title: Prostaglandin E₂ down-regulates the expression of CD25 on bovine T cells, and this effect is mediated through the EP4 receptor.
  4. There is a positive correlation between the intensity of CD25 expression and the expression of the transcription Foxp3 factor in bovine CD8(+) cells.
    Title: Foxp3 expression in bovine CD8+ T cells is associated with the intensity of CD25 expression.
  5. These findings revealed that despite the existence of a distinct bovine CD4(+)CD25(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population
    Title: Subpopulations of bovine WC1(+) gammadelta T cells rather than CD4(+)CD25(high) Foxp3(+) T cells act as immune regulatory cells ex vivo.
  6. Pretreatment of neonatal PBMC with IL-1beta, TNF-alpha or IFN-gamma promotes mitogenic response to ConA through up-regulating the production of IL-2 and the expression of the mature IL-2 receptor.
    Title: Proinflammatory cytokines in bovine colostrum potentiate the mitogenic response of peripheral blood mononuclear cells from newborn calves through IL-2 and CD25 expression.
  7. determined the effects of Mycobacterium-induced proliferation and apoptosis on CD25, CD44, and CD62L expression on peripheral blood T-cell subsets from M. bovis-infected cattle.
    Title: Expression of L-Selectin (CD62L), CD44, and CD25 on activated bovine T cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC155054

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables interleukin-2 binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables interleukin-2 receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interleukin-2 receptor subunit alpha
Names
IL-2 receptor alpha subunit
IL-2 receptor subunit alpha
IL-2-RA
IL-2R alpha
IL-2R subunit alpha
IL2-RA
TAC antigen
cytokine receptor
interleukin 2 receptor, alpha
interleukin-2 receptor alpha chain
p55

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174358.2 → NP_776783.1  interleukin-2 receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_776783.1

    Status: PROVISIONAL

    Source sequence(s)
    M20818
    UniProtKB/Swiss-Prot
    P12342
    UniProtKB/TrEMBL
    A0AAA9SP31
    Related
    ENSBTAP00000092190.1, ENSBTAT00000129500.1
    Conserved Domains (1) summary
    cd00033
    Location:123 → 185
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    17455219..17500715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005214133.5 → XP_005214190.1  interleukin-2 receptor subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_005214190.1

    UniProtKB/TrEMBL
    A0AAA9SP31, A2VE30, E1BEN0, F1MUD7
    Related
    ENSBTAP00000051522.3, ENSBTAT00000054113.4
    Conserved Domains (1) summary
    cd00033
    Location:123 → 185
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12342.1 GenPept UniProtKB/Swiss-Prot:P12342

Gene LinkOut

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