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IL12B interleukin 12B [ Bos taurus (domestic cattle) ]

Gene ID: 281857, updated on 30-Jan-2025
Official Symbol
IL12Bprovided by VGNC
Official Full Name
interleukin 12Bprovided by VGNC
Primary source
VGNC:VGNC:30111
See related
BGD:BT12383; EnsemblRapid:ENSBTAG00070000461
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
IL12p40
Orthologs
human mouse all
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See IL12B in Genome Data Viewer
Location:
chromosome: 7
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (70891451..70911791, complement)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 145 Neighboring gene ubiquitin like domain containing CTD phosphatase 1 Neighboring gene uncharacterized LOC112447645 Neighboring gene transfer RNA cysteine (anticodon ACA)

Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Bovine interleukin-12 and modulation of IFNgamma production. Collins RA, et al. Vet Immunol Immunopathol, 1999 May. PMID 10438320
  2. Production of interleukin-12 as a self-processing 2A polypeptide. Chaplin PJ, et al. J Interferon Cytokine Res, 1999 Mar. PMID 10213462
  3. Enzymatic amplification and molecular cloning of cDNA encoding the small and large subunits of bovine interleukin 12. Zarlenga DS, et al. Biochim Biophys Acta, 1995 Apr 24. PMID 7727547
  4. Mycobacterium avium subspecies paratuberculosis suppresses expression of IL-12p40 and iNOS genes induced by signalling through CD40 in bovine monocyte-derived macrophages. Sommer S, et al. Vet Immunol Immunopathol, 2009 Mar 15. PMID 19022505
  5. Development of detection methods for ruminant interleukin (IL)-12. Hope JC, et al. J Immunol Methods, 2002 Aug 1. PMID 12133628

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results showed that the expression of TNF-alpha, iNOS, and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 was unaffected.[IL-6, IL-12]
    Title: Effect of recombinant Mce4A protein of Mycobacterium bovis on expression of TNF-alpha, iNOS, IL-6, and IL-12 in bovine alveolar macrophages.
  2. study investigated hypothesis that CD40 signalling is impaired in Mycobacterium avium subspecies paratuberculosis(MAP)-infected macrophages; propose that MAP interferes with gene expression of iNOS and IL-12p40 genes downstream of p38
    Title: Mycobacterium avium subspecies paratuberculosis suppresses expression of IL-12p40 and iNOS genes induced by signalling through CD40 in bovine monocyte-derived macrophages.
  3. Lipopolysaccharide stimulation up-regulates the secretion of cytokines, including interleukin-12, by bovine polymorphonuclear neutrophil leukocytes.
    Title: Bacterial lipopolysaccharide stimulates bovine neutrophil production of TNF-alpha, IL-1beta, IL-12 and IFN-gamma.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
interleukin-12 subunit beta
Names
CLMF p40
IL-12 subunit p40
IL-12B
cytotoxic lymphocyte maturation factor 40 kDa subunit
interleukin 12 40kDa subunit
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174356.1 → NP_776781.1  interleukin-12 subunit beta precursor

    See identical proteins and their annotated locations for NP_776781.1

    Status: PROVISIONAL

    Source sequence(s)
    U11815
    UniProtKB/Swiss-Prot
    A9QWR4, P46282
    Conserved Domains (4) summary
    smart00408
    Location:42 → 90
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:42 → 91
    IG_like; Immunoglobulin like
    cd00063
    Location:236 → 324
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam10420
    Location:126 → 217
    IL12p40_C; Cytokine interleukin-12p40 C-terminus

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    70891451..70911791 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010807562.4 → XP_010805864.3  interleukin-12 subunit beta isoform X1

  2. XM_005209679.5 → XP_005209736.2  interleukin-12 subunit beta isoform X2

    UniProtKB/TrEMBL
    A0A3Q1LXM0
    Related
    ENSBTAP00070000711.1, ENSBTAT00070001025.1
    Conserved Domains (3) summary
    smart00408
    Location:42 → 90
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:236 → 324
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam10420
    Location:126 → 217
    IL12p40_C; Cytokine interleukin-12p40 C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46282.1 GenPept UniProtKB/Swiss-Prot:P46282

Gene LinkOut

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