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IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma [ Bos taurus (domestic cattle) ]

Gene ID: 281855, updated on 5-Sep-2025
Official Symbol
IKBKGprovided by VGNC
Official Full Name
inhibitor of nuclear factor kappa B kinase regulatory subunit gammaprovided by VGNC
Primary source
VGNC:VGNC:30102
See related
BGD:BT11757; EnsemblRapid:ENSBTAG00070036108
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See IKBKG in Genome Data Viewer
Location:
chromosome: X
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (37582609..37641404)

Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 10 member 3 Neighboring gene FAM3 metabolism regulating signaling molecule A Neighboring gene glucose-6-phosphate dehydrogenase Neighboring gene putative RNA-binding protein 15B Neighboring gene uncharacterized LOC112445126 Neighboring gene EKC/KEOPS complex subunit LAGE3-like Neighboring gene protein PRRC2B-like Neighboring gene small nucleolar RNA SNORD62

Genomic Sequence:
NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Characterization of the bovine IkappaB kinases (IKK)alpha and IKKbeta, the regulatory subunit NEMO and their substrate IkappaBalpha. Rottenberg S, et al. Gene, 2002 Oct 16. PMID 12459277
  2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of IkappaB kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
NF-kappa-B essential modulator
Names
I-kappa-B kinase gamma
I-kappa-B kinase subunit gamma
IKK-gamma
IKKAP1
IKKG
NEMO
NF-kappa-B essential modifier
ikB kinase subunit gamma
ikB kinase-associated protein 1
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
inhibitor of nuclear factor kappa B kinase subunit gamma

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174354.3 → NP_776779.1  NF-kappa-B essential modulator

    See identical proteins and their annotated locations for NP_776779.1

    Status: PROVISIONAL

    Source sequence(s)
    BC133306
    UniProtKB/Swiss-Prot
    A2VDM3, Q5E9T0, Q5EA16, Q95KU9
    UniProtKB/TrEMBL
    A0AAF6YPS9
    Related
    ENSBTAP00070049108.1, ENSBTAT00070080956.1
    Conserved Domains (3) summary
    pfam11577
    Location:44 → 111
    NEMO; NF-kappa-B essential modulator NEMO
    pfam16516
    Location:259 → 344
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
    cl00459
    Location:182 → 287
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    37582609..37641404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005227728.5 → XP_005227785.1  NF-kappa-B essential modulator isoform X6

    See identical proteins and their annotated locations for XP_005227785.1

    UniProtKB/Swiss-Prot
    A2VDM3, Q5E9T0, Q5EA16, Q95KU9
    UniProtKB/TrEMBL
    A0AAF6YPS9
    Conserved Domains (3) summary
    pfam11577
    Location:44 → 111
    NEMO; NF-kappa-B essential modulator NEMO
    pfam16516
    Location:259 → 344
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
    cl00459
    Location:182 → 287
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

  2. XM_005227729.5 → XP_005227786.1  NF-kappa-B essential modulator isoform X6

    See identical proteins and their annotated locations for XP_005227786.1

    UniProtKB/Swiss-Prot
    A2VDM3, Q5E9T0, Q5EA16, Q95KU9
    UniProtKB/TrEMBL
    A0AAF6YPS9
    Conserved Domains (3) summary
    pfam11577
    Location:44 → 111
    NEMO; NF-kappa-B essential modulator NEMO
    pfam16516
    Location:259 → 344
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
    cl00459
    Location:182 → 287
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

  3. XM_015461503.3 → XP_015316989.1  NF-kappa-B essential modulator isoform X6

    UniProtKB/Swiss-Prot
    A2VDM3, Q5E9T0, Q5EA16, Q95KU9
    UniProtKB/TrEMBL
    A0AAF6YPS9
    Conserved Domains (3) summary
    pfam11577
    Location:44 → 111
    NEMO; NF-kappa-B essential modulator NEMO
    pfam16516
    Location:259 → 344
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
    cl00459
    Location:182 → 287
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

  4. XM_005227726.5 → XP_005227783.1  NF-kappa-B essential modulator isoform X1

    UniProtKB/TrEMBL
    A0AAA9TPF0, A0AAF6YPS9
    Conserved Domains (3) summary
    pfam11577
    Location:79 → 146
    NEMO; NF-kappa-B essential modulator NEMO
    pfam16516
    Location:294 → 379
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
    cl00459
    Location:217 → 322
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

  5. XM_010821547.4 → XP_010819849.1  NF-kappa-B essential modulator isoform X5

    UniProtKB/TrEMBL
    A0AAF6YPS9
    Conserved Domains (3) summary
    pfam11577
    Location:79 → 146
    NEMO; NF-kappa-B essential modulator NEMO
    pfam16516
    Location:294 → 379
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
    cl00459
    Location:217 → 322
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

  6. XM_010821545.4 → XP_010819847.1  NF-kappa-B essential modulator isoform X3

    UniProtKB/TrEMBL
    A0AAF6YPS9
    Conserved Domains (4) summary
    COG1340
    Location:90 → 363
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    pfam11577
    Location:79 → 146
    NEMO; NF-kappa-B essential modulator NEMO
    pfam16516
    Location:287 → 372
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
    cl00459
    Location:217 → 315
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

  7. XM_010821544.4 → XP_010819846.1  NF-kappa-B essential modulator isoform X2

    UniProtKB/TrEMBL
    A0AAF6YPS9
    Conserved Domains (3) summary
    pfam11577
    Location:79 → 146
    NEMO; NF-kappa-B essential modulator NEMO
    pfam16516
    Location:293 → 378
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
    cl00459
    Location:216 → 321
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

  8. XM_010821546.4 → XP_010819848.1  NF-kappa-B essential modulator isoform X4

    UniProtKB/TrEMBL
    A0AAF6YPS9
    Conserved Domains (3) summary
    pfam11577
    Location:79 → 146
    NEMO; NF-kappa-B essential modulator NEMO
    pfam16516
    Location:286 → 371
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
    cl00459
    Location:216 → 314
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

  9. XM_005227727.5 → XP_005227784.1  NF-kappa-B essential modulator isoform X6

    See identical proteins and their annotated locations for XP_005227784.1

    UniProtKB/Swiss-Prot
    A2VDM3, Q5E9T0, Q5EA16, Q95KU9
    UniProtKB/TrEMBL
    A0AAF6YPS9
    Conserved Domains (3) summary
    pfam11577
    Location:44 → 111
    NEMO; NF-kappa-B essential modulator NEMO
    pfam16516
    Location:259 → 344
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
    cl00459
    Location:182 → 287
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

RNA

  1. XR_009493446.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95KU9.1 GenPept UniProtKB/Swiss-Prot:Q95KU9

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