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IKBKB inhibitor of nuclear factor kappa B kinase subunit beta [ Bos taurus (domestic cattle) ]

Gene ID: 281854, updated on 5-Sep-2025
Official Symbol
IKBKBprovided by VGNC
Official Full Name
inhibitor of nuclear factor kappa B kinase subunit betaprovided by VGNC
Primary source
VGNC:VGNC:106778
See related
EnsemblRapid:ENSBTAG00070021408
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See IKBKB in Genome Data Viewer
Location:
chromosome: 27
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 27 NC_037354.1 (37127753..37180365)

Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132344067 Neighboring gene plasminogen activator, tissue type Neighboring gene uncharacterized LOC132344068 Neighboring gene uncharacterized LOC132344069 Neighboring gene DNA polymerase beta Neighboring gene dickkopf WNT signaling pathway inhibitor 4

Genomic Sequence:
NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction. Mohan S, et al. Am J Physiol Cell Physiol, 2009 Jan. PMID 18945937, Free PMC Article
  2. Activation of IKKbeta by glucose is necessary and sufficient to impair insulin signaling and nitric oxide production in endothelial cells. Kim F, et al. J Mol Cell Cardiol, 2005 Aug. PMID 15978611
  3. Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta. Kim F, et al. Arterioscler Thromb Vasc Biol, 2005 May. PMID 15731493
  4. Staphylococcus aureus inhibits nuclear factor kappa B activation mediated by prolactin in bovine mammary epithelial cells. Lara-Zárate L, et al. Microb Pathog, 2011 Nov. PMID 21843629
  5. Characterization of the bovine IkappaB kinases (IKK)alpha and IKKbeta, the regulatory subunit NEMO and their substrate IkappaBalpha. Rottenberg S, et al. Gene, 2002 Oct 16. PMID 12459277

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Staphylococcus aureus infection inhibits nuclear factor kappa B activation mediated by prolactin in bovine mammary epithelial cells.
    Title: Staphylococcus aureus inhibits nuclear factor kappa B activation mediated by prolactin in bovine mammary epithelial cells.
  2. Elevated levels of common free fatty acids found in human serum activate IKKbeta in bovine endothelial cells leading to reduced nitric oxide, and may serve to link pathways involved in inflammation and endothelial dysfunction.
    Title: Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta.
  3. High glucose treatment also activated IKKbeta, and pretreatment with aspirin, a pharmacological inhibitor of IKKbeta, prevented both glucose-induced IKKbeta activation and the effect of high glucose to impair insulin-mediated NO production.
    Title: Activation of IKKbeta by glucose is necessary and sufficient to impair insulin signaling and nitric oxide production in endothelial cells.
  4. High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction.
    Title: High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables IkappaB kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of IkappaB kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
inhibitor of nuclear factor kappa-B kinase subunit beta
Names
I-kappa-B kinase 2
I-kappa-B-kinase beta
IKK-B
IKK-beta
IKK2
NFKBIKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
inhibitor of nuclear factor kappa B kinase beta subunit
nuclear factor NF-kappa-B inhibitor kinase beta
serine/threonine protein kinase IKBKB
NP_776778.1
XP_005226156.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174353.2 → NP_776778.1  inhibitor of nuclear factor kappa-B kinase subunit beta

    See identical proteins and their annotated locations for NP_776778.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ414556
    UniProtKB/Swiss-Prot
    Q95KV0
    UniProtKB/TrEMBL
    A0AAF6YRS5
    Related
    ENSBTAP00070028889.1, ENSBTAT00070048376.1
    Conserved Domains (3) summary
    smart00220
    Location:15 → 290
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14038
    Location:20 → 309
    STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta
    pfam12179
    Location:708 → 741
    IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    37127753..37180365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005226099.5 → XP_005226156.1  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1

    UniProtKB/TrEMBL
    A0AAF6YRS5
    Related
    ENSBTAP00070028914.1, ENSBTAT00070048409.1
    Conserved Domains (2) summary
    smart00220
    Location:15 → 290
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14038
    Location:20 → 309
    STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta

RNA

  1. XR_009493068.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95KV0.1 GenPept UniProtKB/Swiss-Prot:Q95KV0

Gene LinkOut

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