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Tomm70a translocase of outer mitochondrial membrane 70A [ Mus musculus (house mouse) ]

Gene ID: 28185, updated on 8-Feb-2024

Summary

Official Symbol
Tomm70aprovided by MGI
Official Full Name
translocase of outer mitochondrial membrane 70Aprovided by MGI
Primary source
MGI:MGI:106295
See related
Ensembl:ENSMUSG00000022752 AllianceGenome:MGI:106295
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tom70; Tomm70; D16Ium22; D16Ium22e; mKIAA0719; D16Wsu109e; 2610044B22Rik
Summary
Predicted to be involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; positive regulation of interferon-beta production; and regulation of defense response. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human TOMM70 (translocase of outer mitochondrial membrane 70). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 30.1), CNS E11.5 (RPKM 26.0) and 28 other tissues See more
Orthologs
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Genomic context

See Tomm70a in Genome Data Viewer
Location:
16 C1.1; 16 34.22 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (56942077..56974893)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (57121714..57154530)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41073 Neighboring gene STARR-seq mESC enhancer starr_41074 Neighboring gene heterogeneous nuclear ribonucleoprotein M pseudogene Neighboring gene transmembrane protein 45A2 Neighboring gene STARR-positive B cell enhancer ABC_E1927 Neighboring gene STARR-seq mESC enhancer starr_41078 Neighboring gene nitrilase family, member 2 Neighboring gene predicted gene, 16892 Neighboring gene TBC1 domain family, member 23

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mitochondrion targeting sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
mitochondrial import receptor subunit TOM70
Names
mitochondrial precursor proteins import receptor
translocase of outer membrane 70 kDa subunit
translocase of outer mitochondrial membrane 70 homolog A
translocase of outer mitochondrial membrane protein 70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138599.5NP_613065.2  mitochondrial import receptor subunit TOM70

    See identical proteins and their annotated locations for NP_613065.2

    Status: PROVISIONAL

    Source sequence(s)
    AC154625
    Consensus CDS
    CCDS28227.1
    UniProtKB/Swiss-Prot
    Q8BNI6, Q9CZW5
    UniProtKB/TrEMBL
    Q3TSX8
    Related
    ENSMUSP00000129186.2, ENSMUST00000166897.3
    Conserved Domains (2) summary
    sd00006
    Location:117145
    TPR; TPR repeat [structural motif]
    cl26005
    Location:117604
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    56942077..56974893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)