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GRK5 G protein-coupled receptor kinase 5 [ Bos taurus (domestic cattle) ]

Gene ID: 281801, updated on 30-Jan-2025
Official Symbol
GRK5provided by VGNC
Official Full Name
G protein-coupled receptor kinase 5provided by VGNC
Primary source
VGNC:VGNC:29656
See related
EnsemblRapid:ENSBTAG00070023017
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
GPRK5
Orthologs
human mouse all
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See GRK5 in Genome Data Viewer
Location:
chromosome: 26
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 26 NC_037353.1 (39360272..39588332)

Chromosome 26 - NC_037353.1Genomic Context describing neighboring genes Neighboring gene sideroflexin 4 Neighboring gene peroxiredoxin 3 Neighboring gene uncharacterized LOC132343966 Neighboring gene regulator of G protein signaling 10 Neighboring gene TIA1 cytotoxic granule associated RNA binding protein like 1

Genomic Sequence:
NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. Premont RT, et al. J Biol Chem, 1994 Mar 4. PMID 8120045
  2. GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity. Hullmann JE, et al. Circ Res, 2014 Dec 5. PMID 25332207, Free PMC Article
  3. The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha. Sorriento D, et al. Proc Natl Acad Sci U S A, 2008 Nov 18. PMID 19008357, Free PMC Article
  4. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. Wu Z, et al. PLoS One, 2012. PMID 22952844, Free PMC Article
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GRK5, acting in a kinase independent manner, is a facilitator of NFAT activity and part of a DNA-binding complex responsible for pathological hypertrophic gene transcription.
    Title: GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity.
  2. potential GRK5 interacting proteins and the association of GRK5 with DDB1 in cell and the regulation of GRK5 level by DDB1-CUL4 ubiquitin ligase complex-dependent proteolysis pathway
    Title: Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.
  3. GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.
    Title: The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables G protein-coupled receptor kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
G protein-coupled receptor kinase 5
Names
g protein-coupled receptor kinase GRK5
NP_776756.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174331.2 → NP_776756.1  G protein-coupled receptor kinase 5

    See identical proteins and their annotated locations for NP_776756.1

    Status: PROVISIONAL

    Source sequence(s)
    U01206
    UniProtKB/Swiss-Prot
    P43249
    UniProtKB/TrEMBL
    A0AAA9S3E8
    Related
    ENSBTAP00070031212.1, ENSBTAT00070051987.1
    Conserved Domains (3) summary
    cd08752
    Location:53 → 175
    RGS_GRK5; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 5 (GRK5)
    smart00220
    Location:186 → 448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05632
    Location:183 → 495
    STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037353.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    39360272..39588332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43249.1 GenPept UniProtKB/Swiss-Prot:P43249

Gene LinkOut

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