GNRHR gonadotropin releasing hormone receptor [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: GNRHRprovided by VGNC
Official Full Name: gonadotropin releasing hormone receptorprovided by VGNC
Primary source: VGNC:VGNC:29482
See related: BGD:BT23809; EnsemblRapid:ENSBTAG00070000206
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	6	NC_037333.1 (83434759..83452397, complement)

Chromosome 6 - NC_037333.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The GRIA1 polymorphism exists in beef cows but it does not influence antral follicle numbers. The association between GnRHR genotype and age at first calving is likely not causal as this polymorphism is not functional.
Title: Identification of an ionotropic glutamate receptor AMPA1/GRIA1 polymorphism in crossbred beef cows differing in fertility.
There was a significant correlation between frequency profile and timing of puberty among the studied breeds, which seems to suggest that genetic variation within bovine GNRHR gene could explain at least part of the reported variability.
Title: Characterization and validation of bovine gonadotripin releasing hormone receptor (GNRHR) polymorphisms.
These results indicate that GnRHR gene can be a potential marker for improving sperm quality traits, and imply that bulls with GA or CT genotype should be selected in breeding program.
Title: Effects of MboII and BspMI polymorphisms in the gonadotropin releasing hormone receptor (GnRHR) gene on sperm quality in Holstein bulls.
Seven sequence variants (SVs) have been identified in exon 1 and in the promoter region upstream of the bovine gonadotrophin releasing hormone (GnRH) receptor; g.-108T>C alteration was associated with beneficial effects on fertility
Title: Sequence variants in the bovine gonadotrophin releasing hormone receptor gene and their associations with fertility.

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General gene information

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Markers

RW8 (e-PCR)
- UniSTS:241572

GNRHR (e-PCR), detects polymorphism
- UniSTS:278492

MARC_40996-40997:1085147157:1 (e-PCR)
- UniSTS:467428

MARC_40998-40999:1085148472:1 (e-PCR)
- UniSTS:467429

GNRHR (e-PCR), detects polymorphism
- UniSTS:279536

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables peptide binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein-hormone receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to hormone stimulus	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: gonadotropin-releasing hormone receptor

Names: gnRH receptor; gnRH-R; gonadotrophin-releasing hormone receptor; luteinizing-releasing hormone receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177514.2 → NP_803480.1 gonadotropin-releasing hormone receptor

See identical proteins and their annotated locations for NP_803480.1

Status: PROVISIONAL

Source sequence(s)

U00934

UniProtKB/Swiss-Prot

P32236

Related

ENSBTAP00070000240.1, ENSBTAT00070000389.1

Conserved Domains (2) summary

cd14964
Location:38 → 67

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:36 → 328

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

Range

83434759..83452397 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005208022.5 → XP_005208079.1 gonadotropin-releasing hormone receptor isoform X1

Conserved Domains (1) summary

pfam00001
Location:70 → 175

7tm_1; 7 transmembrane receptor (rhodopsin family)