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FGFR1 fibroblast growth factor receptor 1 [ Bos taurus (domestic cattle) ]

Gene ID: 281768, updated on 18-Aug-2024

Summary

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Official Symbol
FGFR1provided by VGNC
Official Full Name
fibroblast growth factor receptor 1provided by VGNC
Primary source
VGNC:VGNC:50179
See related
BGD:BT11580; Ensembl:ENSBTAG00000015457
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 27
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 27 NC_037354.1 (33548428..33599029, complement)

Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor binding SET domain protein 3 Neighboring gene microRNA mir-2400 Neighboring gene LETM1 domain-containing protein LETM2, mitochondrial Neighboring gene LETM1 domain-containing protein LETM2, mitochondrial Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene transfer RNA glycine (anticodon UCC)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Heparan sulphate glycosaminoglycans derived from endothelial cells and smooth muscle cells differentially modulate fibroblast growth factor-2 biological activity through fibroblast growth factor receptor-1. Berry D, et al. Biochem J, 2003 Jul 1. PMID 12659634, Free PMC Article
  2. Stimulatory effects of fibroblast growth factor 2 on proliferation and migration of uterine luminal epithelial cells during early pregnancy. Lim W, et al. Biol Reprod, 2017 Jan 1. PMID 28395342
  3. Somatic cell nuclear transfer is associated with altered expression of angiogenic factor systems in bovine placentomes at term. Campos DB, et al. Genet Mol Res, 2010 Feb 23. PMID 20198587
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. activation of FGFR1 and FGFR2 by uterine- and endometrial-derived FGF2 stimulates PI3K/AKT and mitogen-activated protein kinase pathways for development of the porcine uterus and improvement of litter size
    Title: Stimulatory effects of fibroblast growth factor 2 on proliferation and migration of uterine luminal epithelial cells during early pregnancy.
  2. Alterations in the expression of VEGF-A and bFGF systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
    Title: Somatic cell nuclear transfer is associated with altered expression of angiogenic factor systems in bovine placentomes at term.
  3. Heparan sulfate glycosaminoglycans affect FGF signalling by interacting with both the growth factor and the receptor
    Title: Heparan sulphate glycosaminoglycans derived from endothelial cells and smooth muscle cells differentially modulate fibroblast growth factor-2 biological activity through fibroblast growth factor receptor-1.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC151817

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fibroblast growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fibroblast growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
fibroblast growth factor receptor 1
Names
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
NP_001103677.1
XP_010818626.1
XP_024841961.1
XP_024841962.1
XP_059738149.1
XP_059738150.1
XP_059738151.1
XP_059738152.1
XP_059738153.1
XP_059738155.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110207.1 → NP_001103677.1  fibroblast growth factor receptor 1 precursor

    See identical proteins and their annotated locations for NP_001103677.1

    Status: PROVISIONAL

    Source sequence(s)
    BC134637
    UniProtKB/TrEMBL
    A0A3Q1LUE0, A4IFL5, F1MKA3
    Related
    ENSBTAP00000020550.6, ENSBTAT00000020550.7
    Conserved Domains (7) summary
    cd04973
    Location:40 → 118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:268 → 357
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161 → 245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:260 → 356
    IG_like; Immunoglobulin like
    pfam07679
    Location:158 → 245
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:462 → 763
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:476 → 752
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    33548428..33599029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024986194.2 → XP_024841962.1  fibroblast growth factor receptor 1 isoform X7

    UniProtKB/TrEMBL
    A0A3Q1MDS3
    Conserved Domains (3) summary
    cd05857
    Location:72 → 156
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:179 → 268
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:371 → 672
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

  2. XM_059882170.1 → XP_059738153.1  fibroblast growth factor receptor 1 isoform X6

    UniProtKB/TrEMBL
    A0A3Q1MDS3

  3. XM_059882169.1 → XP_059738152.1  fibroblast growth factor receptor 1 isoform X5

    UniProtKB/TrEMBL
    A0A3Q1MDS3

  4. XM_024986193.2 → XP_024841961.1  fibroblast growth factor receptor 1 isoform X4

    UniProtKB/TrEMBL
    A0A3Q1LUE0
    Conserved Domains (4) summary
    cd04973
    Location:40 → 118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161 → 245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:268 → 357
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:460 → 761
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

  5. XM_059882168.1 → XP_059738151.1  fibroblast growth factor receptor 1 isoform X3

    UniProtKB/TrEMBL
    A0A3Q1LUE0, A4IFL5, F1MKA3

  6. XM_010820324.4 → XP_010818626.1  fibroblast growth factor receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A3Q1LUE0
    Conserved Domains (7) summary
    cd04973
    Location:40 → 118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:270 → 359
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:163 → 247
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:262 → 358
    IG_like; Immunoglobulin like
    pfam07679
    Location:160 → 247
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:462 → 763
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:476 → 752
    Pkinase_Tyr; Protein tyrosine kinase

  7. XM_059882166.1 → XP_059738149.1  fibroblast growth factor receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LUE0, A0AAF6DM05

  8. XM_059882172.1 → XP_059738155.1  fibroblast growth factor receptor 1 isoform X6

    UniProtKB/TrEMBL
    A0A3Q1MDS3
    Related
    ENSBTAP00000068604.1, ENSBTAT00000081422.2

  9. XM_059882167.1 → XP_059738150.1  fibroblast growth factor receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LUE0, A0AAF6DM05
Nucleotide Protein Strain
Heading Accession and Version

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