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CXCR4 C-X-C motif chemokine receptor 4 [ Bos taurus (domestic cattle) ]

Gene ID: 281736, updated on 5-Sep-2025
Official Symbol
CXCR4provided by VGNC
Official Full Name
C-X-C motif chemokine receptor 4provided by VGNC
Primary source
VGNC:VGNC:27856
See related
BGD:BT27276
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See CXCR4 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (61250149..61253862)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104971235 Neighboring gene uncharacterized LOC112442665 Neighboring gene uncharacterized LOC132343063 Neighboring gene aspartyl-tRNA synthetase 1 Neighboring gene minichromosome maintenance complex component 6

Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Cellular detection of the chemokine receptor CXCR4 in bovine mammary glands and its distribution and regulation on bovine leukocytes. Revskij D, et al. J Dairy Sci, 2022 Jan. PMID 34763920
  2. Lack of specific alleles for the bovine chemokine (C-X-C) receptor type 4 (CXCR4) gene in West African cattle questions its role as a candidate for trypanotolerance. Álvarez I, et al. Infect Genet Evol, 2016 Aug. PMID 27117936
  3. C-X-C chemokine receptor type 4 and cytokine expressions in cows of a dairy herd with high prevalence of calves persistently infected with bovine viral diarrhea virus. Helal MA, et al. Jpn J Vet Res, 2013 Aug. PMID 24059096
  4. Sequence and expression of a neuropeptide Y receptor cDNA. Rimland J, et al. Mol Pharmacol, 1991 Dec. PMID 1661837
  5. Stromal cell-derived factor 1 regulates in vitro sperm migration towards the cumulus-oocyte complex in cattle. Umezu K, et al. PLoS One, 2020. PMID 32353075, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cellular detection of the chemokine receptor CXCR4 in bovine mammary glands and its distribution and regulation on bovine leukocytes.
    Title: Cellular detection of the chemokine receptor CXCR4 in bovine mammary glands and its distribution and regulation on bovine leukocytes.
  2. Study identified stromal cell-derived factor 1 (SDF1), which was expressed in bovine cumulus-oocyte complexes (COCs), and its receptor CXCR4 in sperm, as a sperm chemoattractants and proposed that SDF1 is a chemotactic factor for bovine sperm to regulate their migration towards an oocyte via the CXCR4 receptor.
    Title: Stromal cell-derived factor 1 regulates in vitro sperm migration towards the cumulus-oocyte complex in cattle.
  3. The current analysis failed in identifying a causal mutation on the CXCR4 gene underlying a previously reported quantitative trait loci for cattle trypanotolerance on bovine chromosome 2.
    Title: Lack of specific alleles for the bovine chemokine (C-X-C) receptor type 4 (CXCR4) gene in West African cattle questions its role as a candidate for trypanotolerance.
  4. There is a potential link between follicular SDF1/CXCR4 activation and the regulation of ovulation-related genes in cows and horses.
    Title: Expression and regulation of stromal cell-derived factor-1 (SDF1) and chemokine CXC motif receptor 4 (CXCR4) in equine and bovine preovulatory follicles.
  5. The combination of low expression of CXCR4 and high expression of IL-10 might be closely concerned with some bias for the production of PI calves.
    Title: C-X-C chemokine receptor type 4 and cytokine expressions in cows of a dairy herd with high prevalence of calves persistently infected with bovine viral diarrhea virus.
Submit: New GeneRIF Correction

Markers

Homology

Clone Names

  • MGC128682

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables C-C chemokine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables C-C chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
C-X-C chemokine receptor type 4
Names
CXC-R4
CXCR-4
LCR1
LESTR
SDF-1 receptor
chemokine (C-X-C motif) receptor 4
fusin
leukocyte-derived seven transmembrane domain receptor
stromal cell-derived factor 1 receptor

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174301.3 → NP_776726.1  C-X-C chemokine receptor type 4

    See identical proteins and their annotated locations for NP_776726.1

    Status: PROVISIONAL

    Source sequence(s)
    BC105217
    UniProtKB/Swiss-Prot
    P25930, Q3MHJ3
    UniProtKB/TrEMBL
    A0AAF6YI70
    Conserved Domains (2) summary
    cd15179
    Location:40 → 314
    7tmA_CXCR4; CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    pfam12109
    Location:6 → 39
    CXCR4_N; CXCR4 Chemokine receptor N terminal

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    61250149..61253862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25930.1 GenPept UniProtKB/Swiss-Prot:P25930

Gene LinkOut

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