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CREB1 cAMP responsive element binding protein 1 [ Bos taurus (domestic cattle) ]

Gene ID: 281713, updated on 5-Sep-2025
Official Symbol
CREB1provided by VGNC
Official Full Name
cAMP responsive element binding protein 1provided by VGNC
Primary source
VGNC:VGNC:27692
See related
BGD:BT10500; EnsemblRapid:ENSBTAG00070002237
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
CREB
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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See CREB1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (95864818..95897170)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100847666 Neighboring gene mitochondrial import inner membrane translocase subunit Tim17-B-like Neighboring gene methyltransferase 21A, HSPA lysine Neighboring gene BICD cargo adaptor 1 pseudogene Neighboring gene uncharacterized LOC132343233

Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Angiotensin II promotes the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser133 through an ERK1/2-dependent mechanism. Cammarota M, et al. J Neurochem, 2001 Dec. PMID 11752053
  2. The CREB, ATF-1, and ATF-2 transcription factors from bovine leukemia virus-infected B lymphocytes activate viral expression. Adam E, et al. J Virol, 1996 Mar. PMID 8627725, Free PMC Article
  3. Involvement of the cyclic AMP-responsive element binding protein in bovine leukemia virus expression in vivo. Adam E, et al. J Virol, 1994 Sep. PMID 8057465, Free PMC Article
  4. Nucleotide sequence of the bovine cyclic-AMP responsive DNA binding protein (CREB2) cDNA. Willems L, et al. DNA Seq, 1991. PMID 1837490
  5. A cyclic AMP-responsive DNA-binding protein (CREB2) is a cellular transactivator of the bovine leukemia virus long terminal repeat. Willems L, et al. J Virol, 1992 Feb. PMID 1309910, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unlocking the Transcriptional Control of NCAPG in Bovine Myoblasts: CREB1 and MYOD1 as Key Players.
    Title: Unlocking the Transcriptional Control of NCAPG in Bovine Myoblasts: CREB1 and MYOD1 as Key Players.
  2. Transcription Factors ZEB1 and CREB Promote the Transcription of Bovine ABHD5 Gene.
    Title: Transcription Factors ZEB1 and CREB Promote the Transcription of Bovine ABHD5 Gene.
  3. Data indicate that Ser738/742-to-glutamate protein kinase D mutant increased AngII-induced CREB protein and activating transcription factor 2 phosphorylation, and phospho-CREB binding to the steroidogenic acute regulatory protein promoter.
    Title: Angiotensin II-induced protein kinase D activates the ATF/CREB family of transcription factors and promotes StAR mRNA expression.
  4. dsRNA as well as other agonists of endothelial cells elicit signaling mechanisms that include in part CREB phosphorylation mediated by calcium-independent phospholipase A2
    Title: Calcium-independent phospholipase A2 mediates CREB phosphorylation in double-stranded RNA-stimulated endothelial cells.
  5. the p38-MAPK/CREB pathway plays a critical role in TNFalpha-induced VCAM-1 expression
    Title: CAMP-response element-binding protein mediates tumor necrosis factor-alpha-induced vascular cell adhesion molecule-1 expression in endothelial cells.
  6. SUMO-1 has a role in modifying cAMP-response element-binding protein CREB in prolonged hypoxia.
    Title: Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cAMP response element binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of ATF4-CREB1 transcription factor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
cyclic AMP-responsive element-binding protein 1
Names
CREB-1
cyclic AMP-responsive DNA-binding protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174285.1 → NP_776710.1  cyclic AMP-responsive element-binding protein 1

    See identical proteins and their annotated locations for NP_776710.1

    Status: PROVISIONAL

    Source sequence(s)
    X57031
    UniProtKB/Swiss-Prot
    A5PK02, O18957, P27925
    Related
    ENSBTAP00070002918.1, ENSBTAT00070005177.1
    Conserved Domains (2) summary
    cd14690
    Location:269 → 323
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:97 → 135
    pKID; pKID domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    95864818..95897170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27925.2 GenPept UniProtKB/Swiss-Prot:P27925

Gene LinkOut

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Molecular Biology Databases
Research Materials