BGLAP bone gamma-carboxyglutamate protein [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: BGLAPprovided by VGNC
Official Full Name: bone gamma-carboxyglutamate proteinprovided by VGNC
Primary source: VGNC:VGNC:26480
See related: BGD:BT23768
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: BGP
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	3	NC_037330.1 (14551205..14552249, complement)

Chromosome 3 - NC_037330.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.
Title: Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.
Data suggest that helical content of 3 Glu-OCN is 57% and is independent of calcium binding; 3 Glu-OCN contains 3 alpha-helices around a hydrophobic core; study includes first high-resolution structure of bovine 3 Glu-OCN using X-ray crystallography.
Title: X-ray crystal structure of bovine 3 Glu-osteocalcin.
Serum osteocalcin levels in non-periparturient Holstein dairy cows were highest in the youngest cows, decreasing with age until time of first calving. In periparturient cows, serum osteocalcin levels were higher in primiparous than in multiparous cows.
Title: Serum osteocalcin in dairy cows: age-related changes and periparturient variation.
A molecular mechanism of lead toxicity for calcium binding proteins.
Title: The (1)H NMR structure of bovine Pb(2+)-osteocalcin and implications for lead toxicity.
Osteocalcin is released from the bone matrix during bone resorption as intact molecules and fragments; serum osteocalcin should be considered as a marker of bone turnover rather than bone formation
Title: Release of intact and fragmented osteocalcin molecules from bone matrix during bone resorption in vitro.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables hydroxyapatite binding	IEA Inferred from Electronic Annotation more info	PubMed
enables structural constituent of bone	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in bone development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of bone mineralization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to vitamin K	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: osteocalcin

Names: bone Gla protein; gamma-carboxyglutamic acid-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174249.2 → NP_776674.1 osteocalcin preproprotein

See identical proteins and their annotated locations for NP_776674.1

Status: PROVISIONAL

Source sequence(s)

X53699

UniProtKB/Swiss-Prot

A7YEW1, P02820

Conserved Domains (1) summary

smart00069
Location:33 → 97

GLA; Domain containing Gla (gamma-carboxyglutamate) residues