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AGTR1 angiotensin II receptor type 1 [ Bos taurus (domestic cattle) ]

Gene ID: 281607, updated on 5-Sep-2025
Official Symbol
AGTR1provided by VGNC
Official Full Name
angiotensin II receptor type 1provided by VGNC
Primary source
VGNC:VGNC:25745
See related
BGD:BT11709; EnsemblRapid:ENSBTAG00070001461
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See AGTR1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (119465670..119521250, complement)

Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene carboxypeptidase A3 Neighboring gene carboxypeptidase B1 Neighboring gene pre-mRNA-splicing factor SPF27 Neighboring gene uncharacterized LOC132345847

Genomic Sequence:
NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor. Sasaki K, et al. Nature, 1991 May 16. PMID 2041569
  2. TREK-1 K+ channels couple angiotensin II receptors to membrane depolarization and aldosterone secretion in bovine adrenal glomerulosa cells. Enyeart JA, et al. Am J Physiol Endocrinol Metab, 2004 Dec. PMID 15315905
  3. Angiotensin II inhibits native bTREK-1 K+ channels through a PLC-, kinase C-, and PIP2-independent pathway requiring ATP hydrolysis. Liu H, et al. Am J Physiol Cell Physiol, 2007 Aug. PMID 17494631
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Angiotensin II (ANGII) inhibits adrenocortical cell KCNK2 in an ATP dependent, PLC/PKC independent manner.
    Title: Angiotensin II inhibits native bTREK-1 K+ channels through a PLC-, kinase C-, and PIP2-independent pathway requiring ATP hydrolysis.
  2. These results identify bTREK-1 K(+) channels as a pivotal control point where ANG II receptor activation is transduced to depolarization-dependent Ca(2+) entry and aldosterone secretion.
    Title: TREK-1 K+ channels couple angiotensin II receptors to membrane depolarization and aldosterone secretion in bovine adrenal glomerulosa cells.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables C-C chemokine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables C-C chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables angiotensin type II receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
type-1 angiotensin II receptor
Names
AT1
AT1 receptor
angiotensin II receptor 1
angiotensin II type-1 receptor
angiotensin receptor 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174233.2 → NP_776658.1  type-1 angiotensin II receptor

    See identical proteins and their annotated locations for NP_776658.1

    Status: PROVISIONAL

    Source sequence(s)
    X62294
    UniProtKB/Swiss-Prot
    P25104
    UniProtKB/TrEMBL
    Q0VCD5
    Related
    ENSBTAP00070001979.1, ENSBTAT00070003395.1
    Conserved Domains (1) summary
    cd15192
    Location:29 → 313
    7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    119465670..119521250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024990377.2 → XP_024846145.1  type-1 angiotensin II receptor isoform X1

    UniProtKB/Swiss-Prot
    P25104
    UniProtKB/TrEMBL
    Q0VCD5
    Related
    ENSBTAP00070001976.1, ENSBTAT00070003386.1
    Conserved Domains (1) summary
    cd15192
    Location:29 → 313
    7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25104.1 GenPept UniProtKB/Swiss-Prot:P25104

Gene LinkOut

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