ADRB1 adrenoceptor beta 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: ADRB1provided by VGNC
Official Full Name: adrenoceptor beta 1provided by VGNC
Primary source: VGNC:VGNC:50130
See related: BGD:BT10204; EnsemblRapid:ENSBTAG00070022667
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 26

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	26	NC_037353.1 (34512662..34538131)

Chromosome 26 - NC_037353.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

of the beta-adrenergic receptors, adrenergic beta(2)-receptor type was most highly expressed in the mammary gland of dairy cows followed by beta(1) and beta(3)
Title: Detection and quantification of mRNA expression of alpha- and beta-adrenergic receptor subtypes in the mammary gland of dairy cows.
beta 1,2 and 3-adrenergic receptors in cattle were positively associated with hepatic activities of gluconeogenetic enzymes and with plasma glucose levels, suggesting functional importance
Title: Ontogenetic development of mRNA levels and binding sites of hepatic beta-adrenergic receptors in cattle.

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General gene information

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Markers

Adrb1 (e-PCR), detects polymorphism
- UniSTS:256461

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables beta1-adrenergic receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of heart rate by epinephrine-norepinephrine	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: beta-1 adrenergic receptor

Names: adrenergic, beta-1-, receptor; beta-1 adrenoceptor; beta-1 adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194266.1 → NP_919242.1 beta-1 adrenergic receptor

See identical proteins and their annotated locations for NP_919242.1

Status: PROVISIONAL

Source sequence(s)

AF188187

UniProtKB/TrEMBL

Q0ZCB3

Conserved Domains (2) summary

pfam00001
Location:75 → 364

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:67 → 266

7tm_4; Olfactory receptor