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ACVR2A activin A receptor type 2A [ Bos taurus (domestic cattle) ]

Gene ID: 281598, updated on 5-Sep-2025
Official Symbol
ACVR2Aprovided by VGNC
Official Full Name
activin A receptor type 2Aprovided by VGNC
Primary source
VGNC:VGNC:25595
See related
EnsemblRapid:ENSBTAG00070011384
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
ACVR2
Orthologs
human mouse all
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See ACVR2A in Genome Data Viewer
Location:
chromosome: 2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (48279645..48374634, complement)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene methyl-CpG binding domain protein 5 Neighboring gene prothymosin, alpha (gene sequence 28) Neighboring gene uncharacterized LOC112443668 Neighboring gene origin recognition complex subunit 4 Neighboring gene large ribosomal subunit protein uL24-like Neighboring gene NADH dehydrogenase (ubiquinone) complex I, assembly factor 6-like

Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Bovine activin receptor type II cDNA: cloning and tissue expression. Ethier JF, et al. Mol Cell Endocrinol, 1994 Dec. PMID 7534730
  2. Fluorescent in situ localization of the bovine activin receptor type IIA locus on chromosome 2 (2q2.3-2.4). Monteagudo LV, et al. Mamm Genome, 1996 Nov. PMID 8875905
  3. MicroRNA-424/503 cluster members regulate bovine granulosa cell proliferation and cell cycle progression by targeting SMAD7 gene through activin signalling pathway. Pande HO, et al. J Ovarian Res, 2018 May 1. PMID 29716627, Free PMC Article
  4. Uncoupled embryonic and extra-embryonic tissues compromise blastocyst development after somatic cell nuclear transfer. Degrelle SA, et al. PLoS One, 2012. PMID 22701625, Free PMC Article
  5. Genetic variants in the upstream region of activin receptor IIA are associated with female fertility in Japanese Black cattle. Sasaki S, et al. BMC Genet, 2015 Oct 20. PMID 26486459, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miRNA-424/503 cluster members target the SMAD7 and ACVR2A genes which are involved in the activin signalling pathway
    Title: MicroRNA-424/503 cluster members regulate bovine granulosa cell proliferation and cell cycle progression by targeting SMAD7 gene through activin signalling pathway.
  2. This genome-wide association study identified variants in the upstream region of ACVR2A, which were associated with female fertility in Japanese Black cattle.
    Title: Genetic variants in the upstream region of activin receptor IIA are associated with female fertility in Japanese Black cattle.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables activin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables activin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of activin receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
activin receptor type-2A
Names
ACTR-IIA
activin A receptor, type II
activin A receptor, type IIA
activin receptor, type IIA
NP_776652.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174227.3 → NP_776652.1  activin receptor type-2A precursor

    See identical proteins and their annotated locations for NP_776652.1

    Status: PROVISIONAL

    Source sequence(s)
    BC140605
    UniProtKB/Swiss-Prot
    A5D7L7, Q28043
    UniProtKB/TrEMBL
    A0A3Q1LSH5
    Related
    ENSBTAP00070015350.1, ENSBTAT00070025673.1
    Conserved Domains (2) summary
    cd14141
    Location:196 → 485
    STKc_ACVR2a; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor
    pfam01064
    Location:38 → 111
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    48279645..48374634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28043.1 GenPept UniProtKB/Swiss-Prot:Q28043

Gene LinkOut

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