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TLR4 toll like receptor 4 [ Bos taurus (domestic cattle) ]

Gene ID: 281536, updated on 5-Sep-2025
Official Symbol
TLR4provided by VGNC
Official Full Name
toll like receptor 4provided by VGNC
Primary source
VGNC:VGNC:52834
See related
BGD:BT12122; EnsemblRapid:ENSBTAG00070012632
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See TLR4 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (107057826..107068837)

Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene astrotactin 2 Neighboring gene uncharacterized LOC112447849 Neighboring gene transfer RNA serine (anticodon AGA) Neighboring gene tigger transposable element-derived protein 1-like Neighboring gene transfer RNA cysteine (anticodon GCA)

Genomic Sequence:
NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Diversity of the TLR4 Immunity Receptor in Czech Native Cattle Breeds Revealed Using the Pacific Biosciences Sequencing Platform. Novák K, et al. Anim Biotechnol, 2017 Jul 3. PMID 28489974
  2. Molecular characterization and expression profile of partial TLR4 gene in association to mastitis in crossbred cattle. Panigrahi M, et al. Anim Biotechnol, 2014. PMID 24669869
  3. Lipopolysaccharide increases Toll-like receptor 4 and downstream Toll-like receptor signaling molecules expression in bovine endometrial epithelial cells. Fu Y, et al. Vet Immunol Immunopathol, 2013 Jan 15. PMID 23218938
  4. Association of TLR4 polymorphisms with Mycobacterium avium subspecies paratuberculosis infection status in Canadian Holsteins. Sharma BS, et al. Anim Genet, 2015 Oct. PMID 26360329
  5. Lipopolysaccharide initiates inflammation in bovine granulosa cells via the TLR4 pathway and perturbs oocyte meiotic progression in vitro. Bromfield JJ, et al. Endocrinology, 2011 Dec. PMID 21990308, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RAGE-TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages.
    Title: RAGE-TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages.
  2. Lipopolysaccharide (LPS) exposure causes an acute increase in TLR4 gene expression in cultured primary ruminal epithelial cells
    Title: Effects of lipopolysaccharide exposure in primary bovine ruminal epithelial cells.
  3. Toll-like receptors and high mobility group box 1 in granulosa cells during bovine follicle maturation.
    Title: Toll-like receptors and high mobility group box 1 in granulosa cells during bovine follicle maturation.
  4. Single-nucleotide polymorphisms in CLEC7A, CD209 and TLR4 gene and their association with susceptibility to paratuberculosis in Indian cattle.
    Title: Single-nucleotide polymorphisms in CLEC7A, CD209 and TLR4 gene and their association with susceptibility to paratuberculosis in Indian cattle.
  5. SNPs rs8193046 and rs8193060 are likely a potential marker against Mycobacterium avium subspecies paratuberculosis and a selection programme eliminating AG genotype for rs8193046 and CT genotype for rs8193060 might be beneficial in conferring resistance to Mycobacterium avium subspecies paratuberculosis in Indian cattle population
    Title: Genetic association of polymorphisms in bovine TLR2 and TLR4 genes with Mycobacterium avium subspecies paratuberculosis infection in Indian cattle population.
  6. This research reveals the effectiveness of LTF/EcoRI and TLR4/AluI loci as candidates for reproductive performance assessment in Holstein cattle.
    Title: Genetic Polymorphisms in LTF/EcoRI and TLR4/AluI loci as candidates for milk and reproductive performance assessment in Holstein cattle.
  7. Two single nucleotide polymorphisms had significant effects on the milk production for Chinese Holstein, and these SNP could be used for molecular marker-assisted selection of milk production.
    Title: Toll-like receptor 4 gene polymorphisms influence milk production traits in Chinese Holstein cows.
  8. PGE2 downregulates LPS-induced inflammatory responses via the TLR4-NF-kappaB signaling pathway in bovine endometrial epithelial cells.
    Title: PGE(2) downregulates LPS-induced inflammatory responses via the TLR4-NF-κB signaling pathway in bovine endometrial epithelial cells.
  9. Based on the impact of both candidate genes,TLR4 and CACNA2D1, on udder health, linear or generalized linear mixed models was applied for testing the associations of SNPs located in the genes and clinical mastitis
    Title: Dominance effects estimation of TLR4 and CACNA2D1 genes for health and production traits using logistic regression.
  10. a single nucleotide polymorphism of the bovine toll like receptor 4 gene (TLR4) in New Zealand (NZ) Holstein-Friesian x Jersey (HF x J) cross dairy cows was associated with milk production traits
    Title: Variation in the Toll-like Receptor 4 (TLR4) gene affects milk traits in dairy cows.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables lipopolysaccharide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables lipopolysaccharide immune receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in MyD88-dependent toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in detection of lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in toll-like receptor 4 signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
toll-like receptor 4
Names
toll-like receptor 4 immunity-related protein
NP_776623.5

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174198.6 → NP_776623.5  toll-like receptor 4 precursor

    See identical proteins and their annotated locations for NP_776623.5

    Status: PROVISIONAL

    Source sequence(s)
    DQ839566
    UniProtKB/Swiss-Prot
    Q0MW16, Q6GV19, Q9GL65
    Related
    ENSBTAP00070017512.1, ENSBTAT00070028720.1
    Conserved Domains (4) summary
    smart00255
    Location:675 → 816
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:27 → 192
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:375 → 400
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:399 → 558
    PPP1R42; protein phosphatase 1 regulatory subunit 42

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    107057826..107068837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GL65.2 GenPept UniProtKB/Swiss-Prot:Q9GL65

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials