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GRK1 G protein-coupled receptor kinase 1 [ Bos taurus (domestic cattle) ]

Gene ID: 281457, updated on 5-Sep-2025
Official Symbol
GRK1provided by VGNC
Official Full Name
G protein-coupled receptor kinase 1provided by VGNC
Primary source
VGNC:VGNC:29654
See related
EnsemblRapid:ENSBTAG00070010493
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
RHOK
Orthologs
human mouse all
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See GRK1 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 12 NC_037339.1 (86752867..86766529)

Chromosome 12 - NC_037339.1Genomic Context describing neighboring genes Neighboring gene transcription factor Dp-1 Neighboring gene ATPase H+/K+ transporting subunit beta Neighboring gene transmembrane protein 255B Neighboring gene growth arrest specific 6 Neighboring gene uncharacterized LOC112449102

Genomic Sequence:
NC_037339.1 Chromosome 12 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase. Inglese J, et al. J Biol Chem, 1992 Jan 25. PMID 1730692
  2. Regulation of the methylation status of G protein-coupled receptor kinase 1 (rhodopsin kinase). Kutuzov MA, et al. Cell Signal, 2012 Dec. PMID 22846544
  3. Structure of a monomeric variant of rhodopsin kinase at 2.5 Å resolution. Tesmer JJ, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 Jun 1. PMID 22684056, Free PMC Article
  4. Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. Singh P, et al. J Biol Chem, 2008 May 16. PMID 18339619, Free PMC Article
  5. Structural basis for calcium-induced inhibition of rhodopsin kinase by recoverin. Ames JB, et al. J Biol Chem, 2006 Dec 1. PMID 17020884

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The C-terminal segment in GCAP2 confers target selectivity, facilitates membrane binding and provides sensitivity of the membrane localization of the protein to phosphorylation by rhodopsin kinase.
    Title: Regulatory function of the C-terminal segment of guanylate cyclase-activating protein 2.
  2. The methylation status of GRK1 is affected by nucleotide binding and by the levels of free Ca2 + via recoverin.
    Title: Regulation of the methylation status of G protein-coupled receptor kinase 1 (rhodopsin kinase).
  3. crystalline dimer interface was disrupted with a L166K mutation and the structure of GRK1-L166K was determined in complex with Mg(2+) . ATP to 2.5 A resolution
    Title: Structure of a monomeric variant of rhodopsin kinase at 2.5 Å resolution.
  4. A novel rhodopsin-kinase-binding site within the C-terminal region of recoverin.
    Title: Involvement of the recoverin C-terminal segment in recognition of the target enzyme rhodopsin kinase.
  5. similar to transducin activation, rhodopsin phosphorylation by GRK1 and high affinity arrestin-1 binding only requires a rhodopsin monomer
    Title: Monomeric rhodopsin is sufficient for normal rhodopsin kinase (GRK1) phosphorylation and arrestin-1 binding.
  6. key elements of rhodopsin kinase in different ligand states are involved in G protein-coupled receptor kinase activation
    Title: Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation.
  7. Recoverin binds exclusively to an amphipathic peptide at the N terminus of rhodopsin kinase
    Title: Recoverin binds exclusively to an amphipathic peptide at the N terminus of rhodopsin kinase, inhibiting rhodopsin phosphorylation without affecting catalytic activity of the kinase.
  8. Ca(2+)-bound recoverin is bound between rhodopsin and RK in a ternary complex on rod outer segment disk membranes, thereby blocking RK interaction with rhodopsin at high Ca(2+)
    Title: Structural basis for calcium-induced inhibition of rhodopsin kinase by recoverin.
  9. an interaction surface for the recoverin target rhodopsin kinase is constituted upon Ca2+ binding to the non-acylated mutant
    Title: One of the Ca2+ binding sites of recoverin exclusively controls interaction with rhodopsin kinase.
  10. Recoverin and rhodopsin kinase have roles in a Ca2+-dependent feedback loop in membrane rafts from rod outer segments
    Title: Recoverin and rhodopsin kinase activity in detergent-resistant membrane rafts from rod outer segments.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables rhodopsin kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of opsin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
rhodopsin kinase GRK1
Names
RK
NP_776598.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174173.2 → NP_776598.1  rhodopsin kinase GRK1

    See identical proteins and their annotated locations for NP_776598.1

    Status: PROVISIONAL

    Source sequence(s)
    M73836
    UniProtKB/Swiss-Prot
    P28327
    UniProtKB/TrEMBL
    A0A3Q1LUY2
    Related
    ENSBTAP00070013853.1, ENSBTAT00070023455.1
    Conserved Domains (2) summary
    cd08748
    Location:42 → 176
    RGS_GRK1; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 1 (GRK1)
    cd05608
    Location:185 → 472
    STKc_GRK1; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037339.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    86752867..86766529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28327.1 GenPept UniProtKB/Swiss-Prot:P28327

Gene LinkOut

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