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PDYN prodynorphin [ Bos taurus (domestic cattle) ]

Gene ID: 281385, updated on 30-Jan-2025
Official Symbol
PDYNprovided by VGNC
Official Full Name
prodynorphinprovided by VGNC
Primary source
VGNC:VGNC:32723
See related
BGD:BT17558; EnsemblRapid:ENSBTAG00070029008
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
all
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Try the new Transcripts and proteins table
See PDYN in Genome Data Viewer
Location:
chromosome: 13
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (53127708..53148824)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene transfer RNA tyrosine (anticodon GUA) Neighboring gene uncharacterized LOC132346922 Neighboring gene uncharacterized LOC132346923 Neighboring gene signal regulatory protein alpha Neighboring gene signal-regulatory protein beta-1

Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. The permeation of dynorphin A 1-6 across the blood brain barrier and its effect on bovine brain microvessel endothelial cell monolayer permeability. Sloan CD, et al. Peptides, 2012 Dec. PMID 23046728, Free PMC Article
  2. cDNA sequence and expression of bovine prodynorphin. Jiang H, et al. Gene, 1997 Feb 28. PMID 9074507
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The investigation of Dyn A 1-17 metabolism at the blood-brain barrier (BBB) is important since the metabolites exhibit unique biological functions compared to the parent compound.
    Title: The permeation of dynorphin A 1-6 across the blood brain barrier and its effect on bovine brain microvessel endothelial cell monolayer permeability.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables opioid receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sensory perception IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon terminus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
proenkephalin-B
Names
beta-neoendorphin-dynorphin
preprodynorphin
proenkephalin-B preproprotein

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174139.3 → NP_776564.2  proenkephalin-B preproprotein

    Status: VALIDATED

    Source sequence(s)
    NKLS02000013
    UniProtKB/TrEMBL
    A0A3Q1MCT6, E1BDY2
    Related
    ENSBTAP00070039996.1, ENSBTAT00070065924.1
    Conserved Domains (1) summary
    pfam01160
    Location:21 → 67
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    53127708..53148824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015474113.3 → XP_015329599.1  proenkephalin-B isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MCT6, E1BDY2
    Conserved Domains (1) summary
    pfam01160
    Location:21 → 67
    Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95104.1 GenPept UniProtKB/Swiss-Prot:Q95104

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials