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FURIN furin, paired basic amino acid cleaving enzyme [ Bos taurus (domestic cattle) ]

Gene ID: 281374, updated on 5-Sep-2025
Official Symbol
FURINprovided by VGNC
Official Full Name
furin, paired basic amino acid cleaving enzymeprovided by VGNC
Primary source
VGNC:VGNC:29146
See related
BGD:BT11212; EnsemblRapid:ENSBTAG00070011340
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
PACE
Orthologs
human mouse all
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See FURIN in Genome Data Viewer
Location:
chromosome: 21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (21780691..21797132, complement)

Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene mannosidase alpha class 2A member 2 Neighboring gene FES proto-oncogene, tyrosine kinase Neighboring gene BLM RecQ like helicase Neighboring gene uncharacterized LOC107131599 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene CREB regulated transcription coactivator 3

Genomic Sequence:
NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Maturation of the trans-Golgi network protease furin: compartmentalization of propeptide removal, substrate cleavage, and COOH-terminal truncation. Vey M, et al. J Cell Biol, 1994 Dec. PMID 7806563, Free PMC Article
  2. Efficient derivation of bovine embryonic stem cells needs more than active core pluripotency factors. Maruotti J, et al. Mol Reprod Dev, 2012 Jul. PMID 22573702
  3. Forms of selenium in vitamin-mineral mixes differentially affect the expression of genes responsible for prolactin, ACTH, and α-MSH synthesis and mitochondrial dysfunction in pituitaries of steers grazing endophyte-infected tall fescue. Li Q, et al. J Anim Sci, 2019 Feb 1. PMID 30476104, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptide hormone processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
furin
Names
dibasic-processing enzyme
furin, membrane associated receptor protein
paired basic amino acid cleaving enzyme
paired basic amino acid residue-cleaving enzyme
trans Golgi network protease furin
NP_776561.1
XP_024837364.1
XP_024837365.1
XP_024837366.1
XP_059734924.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174136.2 → NP_776561.1  furin precursor

    See identical proteins and their annotated locations for NP_776561.1

    Status: PROVISIONAL

    Source sequence(s)
    X75956
    UniProtKB/Swiss-Prot
    Q28193
    UniProtKB/TrEMBL
    A0A3Q1M727
    Related
    ENSBTAP00070015272.1, ENSBTAT00070025570.1
    Conserved Domains (5) summary
    cd04059
    Location:113 → 402
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638 → 675
    FU; Furin-like repeats
    pfam00082
    Location:144 → 427
    Peptidase_S8; Subtilase family
    pfam01483
    Location:484 → 570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    21780691..21797132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059878941.1 → XP_059734924.1  furin isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M727, B0JYR0

  2. XM_024981598.2 → XP_024837366.1  furin isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M727, B0JYR0
    Conserved Domains (4) summary
    cd04059
    Location:113 → 402
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638 → 675
    FU; Furin-like repeats
    pfam01483
    Location:484 → 570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain

  3. XM_024981597.2 → XP_024837365.1  furin isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M727, B0JYR0
    Conserved Domains (4) summary
    cd04059
    Location:113 → 402
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638 → 675
    FU; Furin-like repeats
    pfam01483
    Location:484 → 570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain

  4. XM_024981596.2 → XP_024837364.1  furin isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M727, B0JYR0
    Conserved Domains (4) summary
    cd04059
    Location:113 → 402
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638 → 675
    FU; Furin-like repeats
    pfam01483
    Location:484 → 570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28193.1 GenPept UniProtKB/Swiss-Prot:Q28193

Gene LinkOut

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