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MSRA methionine sulfoxide reductase A [ Bos taurus (domestic cattle) ]

Gene ID: 281312, updated on 5-Sep-2025
Official Symbol
MSRAprovided by VGNC
Official Full Name
methionine sulfoxide reductase Aprovided by VGNC
Primary source
VGNC:VGNC:31705
See related
EnsemblRapid:ENSBTAG00070002216
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See MSRA in Genome Data Viewer
Location:
chromosome: 8
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (8786080..9169884, complement)

Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132345919 Neighboring gene serine protease 52-like Neighboring gene serine protease 51 Neighboring gene microRNA mir-8548 Neighboring gene uncharacterized LOC132345920 Neighboring gene uncharacterized LOC132345921 Neighboring gene microRNA mir-124a-1

Genomic Sequence:
NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Molecular Expression of Bioactive Recombinant Methionine Sulfoxide Reductase A (MsrA). Indhu MS, et al. Protein Pept Lett, 2021. PMID 32586239
  2. Thionein can serve as a reducing agent for the methionine sulfoxide reductases. Sagher D, et al. Proc Natl Acad Sci U S A, 2006 Jun 6. PMID 16735467, Free PMC Article
  3. The Antioxidant Enzyme Methionine Sulfoxide Reductase A (MsrA) Interacts with Jab1/CSN5 and Regulates Its Function. Jiang B, et al. Antioxidants (Basel), 2020 May 24. PMID 32456285, Free PMC Article
  4. Structure and mechanism of peptide methionine sulfoxide reductase, an "anti-oxidation" enzyme. Lowther WT, et al. Biochemistry, 2000 Nov 7. PMID 11063566
  5. Cloning the expression of a mammalian gene involved in the reduction of methionine sulfoxide residues in proteins. Moskovitz J, et al. Proc Natl Acad Sci U S A, 1996 Mar 5. PMID 8700890, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables L-methionine-(S)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peptide-methionine (S)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
mitochondrial peptide methionine sulfoxide reductase
Names
peptide Met(O) reductase
peptide methionine sulfoxide reductase
peptide-methionine (S)-S-oxide reductase
protein-methionine-S-oxide reductase
NP_776539.1
XP_005209893.1
XP_005209894.1
XP_024851208.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174114.2 → NP_776539.1  mitochondrial peptide methionine sulfoxide reductase

    See identical proteins and their annotated locations for NP_776539.1

    Status: PROVISIONAL

    Source sequence(s)
    U37150
    UniProtKB/TrEMBL
    A0A3Q1M909
    Related
    ENSBTAP00070002860.1, ENSBTAT00070005090.1
    Conserved Domains (1) summary
    PRK00058
    Location:27 → 230
    PRK00058; methionine sulfoxide reductase A; Provisional

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    8786080..9169884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005209836.4 → XP_005209893.1  mitochondrial peptide methionine sulfoxide reductase isoform X2

    UniProtKB/TrEMBL
    A0AAA9RUA0
    Related
    ENSBTAP00070002865.1, ENSBTAT00070005098.1
    Conserved Domains (1) summary
    cl00366
    Location:27 → 190
    PMSR; Peptide methionine sulfoxide reductase

  2. XM_024995440.1 → XP_024851208.1  mitochondrial peptide methionine sulfoxide reductase isoform X1

    Conserved Domains (1) summary
    cl00366
    Location:27 → 144
    PMSR; Peptide methionine sulfoxide reductase

  3. XM_005209837.4 → XP_005209894.1  mitochondrial peptide methionine sulfoxide reductase isoform X3

    UniProtKB/TrEMBL
    A0A3Q1M909, A0AAA9SH81
    Related
    ENSBTAP00070002857.1, ENSBTAT00070005085.1
    Conserved Domains (1) summary
    PRK00058
    Location:1 → 189
    PRK00058; methionine sulfoxide reductase A; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54149.2 GenPept UniProtKB/Swiss-Prot:P54149

Gene LinkOut

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