MC4R melanocortin 4 receptor [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: MC4Rprovided by VGNC
Official Full Name: melanocortin 4 receptorprovided by VGNC
Primary source: VGNC:VGNC:31295
See related: BGD:BT10785; EnsemblRapid:ENSBTAG00070023857
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	24	NC_037351.1 (59163932..59165739, complement)

Chromosome 24 - NC_037351.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

evaluate the association of single nucleotide polymorphisms (SNPs) in MC4R with milk production traits in water buffalo. Based on the SNP data, seven haplotypes were constructed. Three SNPs H1 (AGT), H2 (GAT), and H3 (GAC) accounted for 93.0% of the total individuals. Statistical analysis indicated that the SNP g.1104C>T was significantly associated with milk yield, protein, and fat percentage.
Title: Synonymous single nucleotide polymorphisms in the MC4R gene that are significantly associated with milk production traits in water buffaloes.
The MC4R gene may thus be a candidate gene for carcass traits with MC4R single nucleotide polymorphisms being potentially valuable as genetic markers for economic traits in Hanwoo.
Title: Identification and analysis of MC4R polymorphisms and their association with economic traits of Korean cattle (Hanwoo).
The aim was to estimate the frequency of the SNPs in the MC4R gene and to determine if individual genotypes were associated with several economic traits.
Title: Polymorphisms in MC4R gene and correlations with economic traits in cattle.
The results suggested that -129A>G and 1,069C>G single nucleotide polymorphism of the MC4R gene may be useful as a genetic marker for carcass and meat quality traits in Qinchuan cattle.
Title: Mutations of MC4R gene and its association with economic traits in Qinchuan cattle.
Single nucleotide polymorphisms in 5'-untranslated region of MC4R gene, were detected.
Title: Association between variants in the 5'-untranslated region of the bovine MC4R gene and two growth traits in Nanyang cattle.
results are suggestive that adrenal glucocorticoid production could be regulated through melanocortin 4 receptor
Title: Agouti-related protein antagonizes glucocorticoid production induced through melanocortin 4 receptor activation in bovine adrenal cells: a possible autocrine control.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables melanocyte-stimulating hormone receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: melanocortin receptor 4

Names: MC4-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174110.1 → NP_776535.1 melanocortin receptor 4

See identical proteins and their annotated locations for NP_776535.1

Status: PROVISIONAL

Source sequence(s)

AF265221

UniProtKB/Swiss-Prot

A6QNL9, Q9GLJ8

UniProtKB/TrEMBL

D2CNF1, G7Z063

Related

ENSBTAP00070032229.1, ENSBTAT00070053669.1

Conserved Domains (2) summary

pfam00001
Location:61 → 302

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:51 → 174

7tm_4; Olfactory receptor