U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GP2 glycoprotein 2 [ Homo sapiens (human) ]

Gene ID: 2813, updated on 2-Nov-2024

Summary

Official Symbol
GP2provided by HGNC
Official Full Name
glycoprotein 2provided by HGNC
Primary source
HGNC:HGNC:4441
See related
Ensembl:ENSG00000169347 MIM:602977; AllianceGenome:HGNC:4441
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZAP75
Summary
This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Expression
Restricted expression toward pancreas (RPKM 2558.6) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See GP2 in Genome Data Viewer
Location:
16p12.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (20309574..20327513, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (20240526..20258466, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (20320896..20338835, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723396 Neighboring gene SNRPE pseudogene 3 Neighboring gene uromodulin Neighboring gene protein disulfide isomerase like, testis expressed Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:20397845-20398378

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Meta-analysis identifies common variants associated with body mass index in east Asians.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
EBI GWAS Catalog
New loci associated with kidney function and chronic kidney disease.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp779K0533

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antigen binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within antigen transcytosis by M cells in mucosal-associated lymphoid tissue ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in neutrophil migration IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in zymogen granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
pancreatic secretory granule membrane major glycoprotein GP2
Names
glycoprotein 2 (zymogen granule membrane)
pancreatic zymogen granule membrane associated protein GP2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007240.3NP_001007241.2  pancreatic secretory granule membrane major glycoprotein GP2 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001007241.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AC106796
    Consensus CDS
    CCDS42128.1
    UniProtKB/Swiss-Prot
    A6NFM9, A6NJA8, P55259, Q13338, Q9UIF1
    UniProtKB/TrEMBL
    B2R5R0
    Related
    ENSP00000370767.4, ENST00000381362.8
    Conserved Domains (2) summary
    smart00241
    Location:229480
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:358478
    Zona_pellucida; Zona pellucida-like domain
  2. NM_001007241.3NP_001007242.2  pancreatic secretory granule membrane major glycoprotein GP2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001007242.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AC106796
    Consensus CDS
    CCDS45433.1
    UniProtKB/TrEMBL
    Q8N1A3
    Related
    ENSP00000370765.5, ENST00000381360.9
    Conserved Domains (2) summary
    smart00241
    Location:82333
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:211331
    Zona_pellucida; Zona pellucida-like domain
  3. NM_001007242.3NP_001007243.2  pancreatic secretory granule membrane major glycoprotein GP2 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001007243.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 5' coding region compared to variant 1. The resulting protein (isoform 4, also known as beta) is shorter than isoform 1.
    Source sequence(s)
    AC106796
    Consensus CDS
    CCDS45432.1
    UniProtKB/TrEMBL
    Q8N1A3
    Related
    ENSP00000343861.5, ENST00000341642.9
    Conserved Domains (2) summary
    smart00241
    Location:79330
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:208328
    Zona_pellucida; Zona pellucida-like domain
  4. NM_001502.4NP_001493.2  pancreatic secretory granule membrane major glycoprotein GP2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001493.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2, also known as alpha) is shorter than isoform 1.
    Source sequence(s)
    AC106796
    Consensus CDS
    CCDS10582.2
    UniProtKB/TrEMBL
    B2R5R0
    Related
    ENSP00000304044.6, ENST00000302555.10
    Conserved Domains (2) summary
    smart00241
    Location:226477
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:355475
    Zona_pellucida; Zona pellucida-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    20309574..20327513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    20240526..20258466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)