MC1R melanocortin 1 receptor [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: MC1Rprovided by VGNC
Official Full Name: melanocortin 1 receptorprovided by VGNC
Primary source: VGNC:VGNC:106814
See related: BGD:BT11377; EnsemblRapid:ENSBTAG00070031759
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: MSHR; MC1-R
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	18	NC_037345.1 (14705093..14706843)

Chromosome 18 - NC_037345.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of two new recessive MC1R alleles in red-coloured Evolener cattle and other breeds.
Title: Identification of two new recessive MC1R alleles in red-coloured Evolèner cattle and other breeds.
Discovery of a new nucleotide substitution in the MC1R gene and haplotype distribution in native and non-Japanese chicken breeds.
Title: Discovery of a new nucleotide substitution in the MC1R gene and haplotype distribution in native and non-Japanese chicken breeds.
MC1R c.310G>- and c.871G > A determine the coat color of Kumamoto sub-breed of Japanese Brown cattle.
Title: MC1R c.310G>- and c.871G > A determine the coat color of Kumamoto sub-breed of Japanese Brown cattle.
The e and E+ are the main MC1R haplotypes in taurine or intermediate breeds from China. The haplotypes defined by c.416C>T, c.583C>T and c.890T>C, found mostly in China and Bangladesh, are the typical haplotypes of Bos indicus.
Title: New variants in the melanocortin 1 receptor gene (MC1R) in Asian cattle.
Recombinants in a 5 Mb region surrounding the cluster of tyrosine kinase receptor genes implicated PDGFRA as the strongest positional candidate gene interacting with MC1R and modifying black coat color in an F Nellore-Angus population.
Title: Identification of a major locus interacting with MC1R and modifying black coat color in an F₂ Nellore-Angus population.
Six solid colors occur in Highland cattle: black, dun, silver dun and red, yellow, and white. These six coat colors are explained by a non-epistatic interaction of the genotypes at the MC1R and PMEL genes.
Title: Interaction of MC1R and PMEL alleles on solid coat colors in Highland cattle.
the relationship of polymorphism of the MC1R with coat colour
Title: Isolation and characteristics of the melanocortin 1 receptor gene (MC1R) in the Chinese yakow (Bos grunniens×Bos taurus).
In China Holstein Black-white Cattle, China Holstein Red-white Cattle, Luxi Yellow Cattle and Bohai Black Cattle, three alleles (ED, E+ and e) in MC1R were identified and important SNP at 725 position of the MC1R coding region was found.
Title: [Relationship between the melanocortin receptor 1 (MC1R) gene and the coat color phenotype in cattle].
Sequence analysis revealed variation in the TYRP1 (exon 5) and MC1R genes; restriction enzyme analysis of these two genes could distinguish between different colours of Hanwoo cattle.
Title: Molecular variation in pigmentation genes contributing to coat colour in native Korean Hanwoo cattle.

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General gene information

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Markers

M73K (e-PCR), detects polymorphism
- UniSTS:254151

D121N (e-PCR), detects polymorphism
- UniSTS:254152

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables melanocyte-stimulating hormone receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: melanocyte-stimulating hormone receptor

Names: BDF3; MSH-R; alpha melanocyte stimulating hormone receptor; melanocortin receptor 1; melanotropin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174108.2 → NP_776533.1 melanocyte-stimulating hormone receptor

See identical proteins and their annotated locations for NP_776533.1

Status: PROVISIONAL

Source sequence(s)

AF445642

UniProtKB/TrEMBL

A0A059V8X4, Q8WMC6

Related

ENSBTAP00070043847.1, ENSBTAT00070071816.1

Conserved Domains (1) summary

cd15351
Location:39 → 309

7tmA_MC1R; melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors