IGF1 insulin like growth factor 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: IGF1provided by VGNC
Official Full Name: insulin like growth factor 1provided by VGNC
Primary source: VGNC:VGNC:30076
See related: BGD:BT11525; EnsemblRapid:ENSBTAG00070018183
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: IGF-1; IGF-I
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	5	NC_037332.1 (66186011..66264048, complement)

Chromosome 5 - NC_037332.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[The lipidosis of the liver of dairy cows: Part 1 - Role of insulin and the Growth Hormone-IGF-1 axis].
Title: [The lipidosis of the liver of dairy cows: Part 1 - Role of insulin and the Growth Hormone-IGF-1 axis].
Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development.
Title: Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development.
Insulin-like growth factor-1 induces IRE1-XBP1-dependent endoplasmic reticulum biogenesis in bovine mammary epithelial cells.
Title: Insulin-like growth factor-1 induces IRE1-XBP1-dependent endoplasmic reticulum biogenesis in bovine mammary epithelial cells.
the addition of PAPP-A did not affect embryo yield and blastocyst survival, higher IGF-1 levels may affect embryo competence through differential expression of genes involved in lipid metabolism, oocyte competence, and mitochondrial function.
Title: Use of pregnancy-associated plasma protein-A during oocyte in vitro maturation increases IGF-1 and affects the transcriptional profile of cumulus cells and embryos from Nelore cows.
This study showed that the IGF-1 SnaBI TT appears to be associated with fewer days to ovulation and lesser calving to conseption interval of lactating dairy cows and had an additive association with the GHR AluI T allele on indicators for improvement of fertility.
Title: Association of polymorphisms in the IGF-I, GHR and STAT5A genes with serum IGF-I concentration and reproductive performance of Holstein dairy cows.
LncRNA H19 participated in the regulation of the proliferation and apoptosis of male germline stem cells via the IGF-1 signaling pathway
Title: H19 regulates the proliferation of bovine male germline stem cells via IGF-1 signaling pathway.
plasma insulin-like peptide 3, testosterone, inhibin, and insulin-like growth factor-I have a relationship with scrotal circumference and testicular weight in Japanese Black beef bull calves
Title: Relationships of plasma insulin-like peptide 3, testosterone, inhibin, and insulin-like growth factor-I concentrations with scrotal circumference and testicular weight in Japanese Black beef bull calves.
These results suggest that reduced secretions of IGF-I, INSL3, and inhibin surrounding puberty may be associated with semen aberration in beef bulls.
Title: Plasma IGF-I, INSL3, testosterone, inhibin concentrations and scrotal circumferences surrounding puberty in Japanese Black beef bulls with normal and abnormal semen.
IGF1/RsaI was associated with average daily weight gain in cattle.
Title: Polymorphism of Insulin-like Growth Factor 1 Gene (IGF1/TasI, IGF1/SnaBI, IGF1/RsaI) and the Association with Daily Gain of Pesisir Cattle Local Breed from West Sumatera, Indonesia.
Thus CR suppresses the hypertrophic PGC1alpha-4/IGF-1/AKT1 pathway while promoting activation of the calpain system.
Title: Reduced skeletal muscle fiber size following caloric restriction is associated with calpain-mediated proteolysis and attenuation of IGF-1 signaling.

Submit: New GeneRIF Correction See all GeneRIFs (63)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482382

IGF-1-4 (e-PCR)
- UniSTS:253865

IGF1 (e-PCR), detects polymorphism
- UniSTS:250858

IGF-1-5 (e-PCR)
- UniSTS:251115

MARC_16386-16387:1017081416:1 (e-PCR)
- UniSTS:268018

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed
enables insulin-like growth factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: insulin-like growth factor 1

Names: class 1 insulin-like growth factor I preproprotein; insulin growth factor-1; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor I (somatomedin C); prepro-IGF-I; somatomedin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077828.1 → NP_001071296.1 insulin-like growth factor 1 preproprotein

See identical proteins and their annotated locations for NP_001071296.1

Status: PROVISIONAL

Source sequence(s)

BC126802

UniProtKB/Swiss-Prot

P07455

UniProtKB/TrEMBL

F2X2F0, Q9N1C1

Related

ENSBTAP00070024529.1, ENSBTAT00070041099.1

Conserved Domains (1) summary

cd04368
Location:50 → 117

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

Range

66186011..66264048 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005206497.5 → XP_005206554.1 insulin-like growth factor 1 isoform X5

See identical proteins and their annotated locations for XP_005206554.1

UniProtKB/TrEMBL

A0AAF6YVL2, Q9N1C1

Related

ENSBTAP00070024523.1, ENSBTAT00070041089.1

Conserved Domains (1) summary

cd04368
Location:49 → 116

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
XM_005206499.5 → XP_005206556.1 insulin-like growth factor 1 isoform X7

See identical proteins and their annotated locations for XP_005206556.1

UniProtKB/TrEMBL

F2X2F2, Q9N1C1

Conserved Domains (1) summary

cd04368
Location:34 → 101

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
XM_005206500.5 → XP_005206557.1 insulin-like growth factor 1 isoform X8

See identical proteins and their annotated locations for XP_005206557.1

UniProtKB/TrEMBL

Q9N1C1

Conserved Domains (1) summary

cd04368
Location:33 → 100

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
XM_059886094.1 → XP_059742077.1 insulin-like growth factor 1 isoform X1

UniProtKB/TrEMBL

F2X2F1, G3N086
XM_024991342.2 → XP_024847110.1 insulin-like growth factor 1 isoform X6

Related

ENSBTAP00070024516.1, ENSBTAT00070041080.1

Conserved Domains (1) summary

cd04368
Location:50 → 117

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
XM_015471064.3 → XP_015326550.1 insulin-like growth factor 1 isoform X4

UniProtKB/TrEMBL

G3N086

Conserved Domains (2) summary

cd04368
Location:33 → 100

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

pfam15724
Location:108 → 157

TMEM119; TMEM119 family
XM_015471062.3 → XP_015326548.1 insulin-like growth factor 1 isoform X2

UniProtKB/TrEMBL

G3N086

Related

ENSBTAP00070024514.1, ENSBTAT00070041076.1

Conserved Domains (2) summary

cd04368
Location:49 → 116

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

pfam15724
Location:124 → 173

TMEM119; TMEM119 family
XM_015471061.3 → XP_015326547.1 insulin-like growth factor 1 isoform X1

UniProtKB/TrEMBL

F2X2F1, G3N086

Conserved Domains (2) summary

cd04368
Location:50 → 117

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

pfam15724
Location:125 → 174

TMEM119; TMEM119 family
XM_015471063.3 → XP_015326549.1 insulin-like growth factor 1 isoform X3

UniProtKB/TrEMBL

F2X2F3, G3N086

Related

ENSBTAP00070024501.1, ENSBTAT00070041055.1

Conserved Domains (2) summary

cd04368
Location:34 → 101

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

pfam15724
Location:109 → 158

TMEM119; TMEM119 family