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HRH1 histamine receptor H1 [ Bos taurus (cattle) ]

Gene ID: 281231, updated on 5-Apr-2024

Summary

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Gene symbol
HRH1
Gene description
histamine receptor H1
See related
BGD:BT17475; Ensembl:ENSBTAG00000061643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (55182770..55293118)

Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 1 Neighboring gene store-operated calcium entry-associated regulatory factor-like Neighboring gene autophagy related 7 Neighboring gene uncharacterized LOC104975600 Neighboring gene uncharacterized LOC132343526 Neighboring gene vestigial like family member 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression cloning of a cDNA encoding the bovine histamine H1 receptor. Yamashita M, et al. Proc Natl Acad Sci U S A, 1991 Dec 15. PMID 1722337, Free PMC Article
  2. Extraction of membrane cholesterol disrupts caveolae and impairs serotonergic (5-HT2A) and histaminergic (H1) responses in bovine airway smooth muscle: role of Rho-kinase. Sommer B, et al. Can J Physiol Pharmacol, 2009 Mar. PMID 19295659
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.
    Title: Extraction of membrane cholesterol disrupts caveolae and impairs serotonergic (5-HT2A) and histaminergic (H1) responses in bovine airway smooth muscle: role of Rho-kinase.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled serotonin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histamine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables neurotransmitter receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histamine H1 receptor
Names
H1R
HH1R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174083.4 → NP_776508.2  histamine H1 receptor

    See identical proteins and their annotated locations for NP_776508.2

    Status: VALIDATED

    Source sequence(s)
    BC140475
    UniProtKB/Swiss-Prot
    P30546
    UniProtKB/TrEMBL
    A5D795
    Related
    ENSBTAP00000077431.1, ENSBTAT00000132510.1
    Conserved Domains (1) summary
    cd15050
    Location:30 → 483
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    55182770..55293118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010817877.4 → XP_010816179.1  histamine H1 receptor isoform X1

    See identical proteins and their annotated locations for XP_010816179.1

    UniProtKB/Swiss-Prot
    P30546
    UniProtKB/TrEMBL
    A5D795
    Related
    ENSBTAP00000092235.1, ENSBTAT00000109110.1
    Conserved Domains (1) summary
    cd15050
    Location:30 → 483
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_059879455.1 → XP_059735438.1  histamine H1 receptor isoform X1

    UniProtKB/TrEMBL
    A5D795
    Related
    ENSBTAP00000074614.1, ENSBTAT00000126985.1

  3. XM_024982371.2 → XP_024838139.1  histamine H1 receptor isoform X1

    UniProtKB/Swiss-Prot
    P30546
    UniProtKB/TrEMBL
    A5D795
    Conserved Domains (1) summary
    cd15050
    Location:30 → 483
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30546.1 GenPept UniProtKB/Swiss-Prot:P30546

Gene LinkOut

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