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GPX1 glutathione peroxidase 1 [ Bos taurus (cattle) ]

Gene ID: 281209, updated on 27-Aug-2018

Summary

Gene symbol
GPX1
Gene description
glutathione peroxidase 1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Summary
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. There is a direct correlation between the concentration of selenium and the activity of this enzyme in lactating cows, with the highest levels observed during the early stage of lactation, suggesting that the generation of reactive oxygen species was higher during this period compared to the late stage. [provided by RefSeq, Jul 2016]
Orthologs

Genomic context

See GPX1 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
2
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 22 NC_037349.1 (50752554..50753722)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 22 AC_000179.1 (51325106..51326274)

Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene T cell leukemia translocation altered Neighboring gene ras homolog family member A Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC107131694

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of supramolecular fiber organization IDA
Inferred from Direct Assay
more info
PubMed 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glutathione peroxidase 1
Names
GPx-1
GSHPx-1
cellular glutathione peroxidase
NP_776501.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174076.3NP_776501.1  glutathione peroxidase 1

    See identical proteins and their annotated locations for NP_776501.1

    Status: REVIEWED

    Source sequence(s)
    CK969193, EE243568, X13684
    UniProtKB/Swiss-Prot
    P00435
    Conserved Domains (1) summary
    cd00340
    Location:18195
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037349.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    50752554..50753722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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