MSTN myostatin [Bos taurus (cattle)] - Gene

Summary

Official Symbol: MSTNprovided by VGNC
Official Full Name: myostatinprovided by VGNC
Primary source: VGNC:VGNC:31709
See related: BGD:BT12005; EnsemblRapid:ENSBTAG00000011808
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: GDF8
Summary: This gene encodes a member of the TGF-beta (transforming growth factor-beta) family of proteins. The encoded preproprotein is proteolytically processed to generate an N-terminal propeptide and a C-terminal subunit. The C-terminal subunits form the mature homodimer, which negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jun 2016]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	2	NC_037329.1 (6278864..6285491)

Chromosome 2 - NC_037329.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Combined Transcriptome and Metabolome Analysis of Smooth Muscle of Myostatin Knockout Cattle.
Title: Combined Transcriptome and Metabolome Analysis of Smooth Muscle of Myostatin Knockout Cattle.
Association between polymorphisms of Myf5, MSTN and CAST genes and fattening performance in Brown Swiss and Holstein cattle breeds.
Title: Association between polymorphisms of Myf5, MSTN and CAST genes and fattening performance in Brown Swiss and Holstein cattle breeds.
MSTN Mutant Promotes Myogenic Differentiation by Increasing Demethylase TET1 Expression via the SMAD2/SMAD3 Pathway.
Title: MSTN Mutant Promotes Myogenic Differentiation by Increasing Demethylase TET1 Expression via the SMAD2/SMAD3 Pathway.
Myostatin site-directed mutation and simultaneous PPARgamma site-directed knockin in bovine genome.
Title: Myostatin site-directed mutation and simultaneous PPARγ site-directed knockin in bovine genome.
Proteomics insights into the effects of MSTN on muscle glucose and lipid metabolism in genetically edited cattle.
Title: Proteomics insights into the effects of MSTN on muscle glucose and lipid metabolism in genetically edited cattle.
Identified conserved polymorphisms in coding and non-coding regions of bovine MSTN gene. Variations in MSTN might affect growth and carcass traits in NZ cattle.
Title: Genetic variations and haplotypic diversity in the Myostatin gene of New Zealand cattle breeds.
The MSTN-F94L variant was the most strongly associated with five traits (birth weight, calving ease direct, milk, weaning weight and yield grade) among the 13 measured traits in pure-bred Limousin and admixed Limousin and Limousin-Angus populations.
Title: Increasing the accuracy of genomic prediction in pure-bred Limousin beef cattle by including cross-bred Limousin data and accounting for an F94L variant in MSTN.
may have an intraovarian autocrine/paracrine role to modulate thecal and granulosal steroidogenesis and cell proliferation/survival
Title: Myostatin is expressed in bovine ovarian follicles and modulates granulosal and thecal steroidogenesis.
GH/HpaII locus as candidate marker for body weight in cattle rather than MSTN/DraI.
Title: Effect of Genetic Polymorphisms in GH/Hpa II and MSTN / Dra I Loci on Body Weight in Friesian Bull Calves.
Data indicate that the the promoter trap vector PIII-myostatin could knock out the bovine myostatin gene.
Title: A promoter trap vector for knocking out bovine myostatin gene with high targeting efficiency.

Submit: New GeneRIF Correction See all GeneRIFs (37)

General gene information

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Markers

GDF8 (e-PCR), detects polymorphism
- UniSTS:519062

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: growth/differentiation factor 8

Names: GDF-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001525.3 → NP_001001525.1 growth/differentiation factor 8 precursor

See identical proteins and their annotated locations for NP_001001525.1

Status: VALIDATED

Source sequence(s)

BC134563, DAAA02003905

UniProtKB/Swiss-Prot

A4IFF8, O18829, O18836, Q564D4, Q8WNS6, Q95N97

UniProtKB/TrEMBL

A4ZVC5, C6KEF7

Related

ENSBTAP00000015674.4, ENSBTAT00000015674.6

Conserved Domains (2) summary

pfam00688
Location:36 → 236

TGFb_propeptide; TGF-beta propeptide

cd19388
Location:268 → 375

TGF_beta_GDF8; transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 8 (GDF8) and similar proteins