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MSTN myostatin [ Bos taurus (cattle) ]

Gene ID: 281187, updated on 8-Aug-2018

Summary

Official Symbol
MSTNprovided by VGNC
Official Full Name
myostatinprovided by VGNC
Primary source
VGNC:VGNC:31709
See related
BGD:BT12005; Ensembl:ENSBTAG00000011808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
GDF8
Summary
This gene encodes a member of the TGF-beta (transforming growth factor-beta) family of proteins. The encoded preproprotein is proteolytically processed to generate an N-terminal propeptide and a C-terminal subunit. The C-terminal subunits form the mature homodimer, which negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jun 2016]
Orthologs

Genomic context

See MSTN in Genome Data Viewer
Location:
2q14-q15
Exon count:
3
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 2 NC_037329.1 (6278864..6285491)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 2 AC_000159.1 (6213566..6220196)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene 3-hydroxyisobutyryl-CoA hydrolase Neighboring gene chromosome 2 C2orf88 homolog Neighboring gene protein kish-A pseudogene Neighboring gene PMS1 homolog 1, mismatch repair system component Neighboring gene ORMDL sphingolipid biosynthesis regulator 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
 
muscle cell cellular homeostasis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of skeletal muscle tissue growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
growth/differentiation factor 8
Names
GDF-8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001525.3NP_001001525.1  growth/differentiation factor 8 precursor

    See identical proteins and their annotated locations for NP_001001525.1

    Status: VALIDATED

    Source sequence(s)
    BC134563, DAAA02003905
    UniProtKB/Swiss-Prot
    O18836
    UniProtKB/TrEMBL
    C6KEF7
    Related
    ENSBTAP00000015674.4, ENSBTAT00000015674.4
    Conserved Domains (2) summary
    smart00204
    Location:281375
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:39249
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    6278864..6285491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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