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FUT2 fucosyltransferase 2 (H blood group) [ Bos taurus (domestic cattle) ]

Gene ID: 281175, updated on 30-Jan-2025
Gene symbol
FUT2
Gene description
fucosyltransferase 2 (H blood group)
See related
BGD:BT29286; EnsemblRapid:ENSBTAG00070036685
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
Se; sec1
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See FUT2 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (55328189..55340024)

Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene carbonic anhydrase 11 Neighboring gene alpha-2-fucosyltransferase Sec1 Neighboring gene netrin 5 Neighboring gene MEF2 activating motif and SAP domain containing transcriptional regulator Neighboring gene Ras interacting protein 1

Genomic Sequence:
NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Three bovine alpha2-fucosyltransferase genes encode enzymes that preferentially transfer fucose on Galbeta1-3GalNAc acceptor substrates. Barreaud JP, et al. Glycobiology, 2000 Jun. PMID 10814703
  2. Organization of the bovine alpha 2-fucosyltransferase gene cluster suggests that the Sec1 gene might have been shaped through a nonautonomous L1-retrotransposition event within the same locus. Saunier K, et al. Mol Biol Evol, 2001 Nov. PMID 11606704
  3. RNA-mediated gene silencing of FUT1 and FUT2 influences expression and activities of bovine and human fucosylated nucleolin and inhibits cell adhesion and proliferation. Palumberi D, et al. J Cell Biochem, 2010 Sep 1. PMID 20506485
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that si-RNA induced down-regulation of FUT1 and FUT2 reduced expression of fucosylated nucleolin glycoforms and their exposure at the cell surface.
    Title: RNA-mediated gene silencing of FUT1 and FUT2 influences expression and activities of bovine and human fucosylated nucleolin and inhibits cell adhesion and proliferation.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables galactoside 2-alpha-L-fucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in fucosylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
galactoside alpha-(1,2)-fucosyltransferase 2
Names
GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2
alpha(1,2)FT 2
alpha(1-2) fucosyltransferase sec1
fucosyltransferase 2 (secretor status included)
galactoside 2-alpha-L-fucosyltransferase 2
secretor factor
type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2
type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2
NP_803466.1
XP_005219210.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177500.1 → NP_803466.1  galactoside alpha-(1,2)-fucosyltransferase 2

    See identical proteins and their annotated locations for NP_803466.1

    Status: PROVISIONAL

    Source sequence(s)
    X99620
    UniProtKB/Swiss-Prot
    Q28113
    UniProtKB/TrEMBL
    F1MUS1
    Conserved Domains (1) summary
    pfam01531
    Location:21 → 334
    Glyco_transf_11; Glycosyl transferase family 11

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    55328189..55340024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005219153.5 → XP_005219210.1  galactoside alpha-(1,2)-fucosyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_005219210.1

    UniProtKB/TrEMBL
    A0AAA9TA90, F1MUS1
    Related
    ENSBTAP00070049775.1, ENSBTAT00070082186.1
    Conserved Domains (1) summary
    pfam01531
    Location:21 → 334
    Glyco_transf_11; Glycosyl transferase family 11
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28113.2 GenPept UniProtKB/Swiss-Prot:Q28113

Gene LinkOut

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Molecular Biology Databases
Research Materials