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FUT1 fucosyltransferase 1 [ Bos taurus (domestic cattle) ]

Gene ID: 281174, updated on 20-Feb-2025
Official Symbol
FUT1provided by VGNC
Official Full Name
fucosyltransferase 1provided by VGNC
Primary source
VGNC:VGNC:49145
See related
BGD:BT12107; EnsemblRapid:ENSBTAG00070036753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See FUT1 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (55377395..55382481, complement)

Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene Ras interacting protein 1 Neighboring gene izumo sperm-oocyte fusion 1 Neighboring gene fibroblast growth factor 21 Neighboring gene branched chain amino acid transaminase 2 Neighboring gene uncharacterized LOC101903281

Genomic Sequence:
NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Three bovine alpha2-fucosyltransferase genes encode enzymes that preferentially transfer fucose on Galbeta1-3GalNAc acceptor substrates. Barreaud JP, et al. Glycobiology, 2000 Jun. PMID 10814703
  2. Organization of the bovine alpha 2-fucosyltransferase gene cluster suggests that the Sec1 gene might have been shaped through a nonautonomous L1-retrotransposition event within the same locus. Saunier K, et al. Mol Biol Evol, 2001 Nov. PMID 11606704
  3. RNA-mediated gene silencing of FUT1 and FUT2 influences expression and activities of bovine and human fucosylated nucleolin and inhibits cell adhesion and proliferation. Palumberi D, et al. J Cell Biochem, 2010 Sep 1. PMID 20506485
  4. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  5. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that si-RNA induced down-regulation of FUT1 and FUT2 reduced expression of fucosylated nucleolin glycoforms and their exposure at the cell surface.
    Title: RNA-mediated gene silencing of FUT1 and FUT2 influences expression and activities of bovine and human fucosylated nucleolin and inhibits cell adhesion and proliferation.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables galactoside 2-alpha-L-fucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in fucosylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
galactoside alpha-(1,2)-fucosyltransferase 1
Names
GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1
alpha(1,2)FT 1
alpha(1-2) fucosyltransferase 1
blood group H alpha 2-fucosyltransferase
fucosyltransferase 1 (H blood group)
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
galactoside 2-alpha-L-fucosyltransferase 1
type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1
type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1
NP_803465.3
XP_005219208.2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177499.4 → NP_803465.3  galactoside alpha-(1,2)-fucosyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    NKLS02000018
    UniProtKB/Swiss-Prot
    F6Q1T7, Q9TTY7
    UniProtKB/TrEMBL
    F1MS89
    Related
    ENSBTAP00070049848.1, ENSBTAT00070082334.1

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    55377395..55382481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005219151.5 → XP_005219208.2  galactoside alpha-(1,2)-fucosyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A0AAA9TC97, Q0V8Q6
    Related
    ENSBTAP00070049835.1, ENSBTAT00070082310.1
    Conserved Domains (1) summary
    pfam01531
    Location:98 → 409
    Glyco_transf_11; Glycosyl transferase family 11
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F6Q1T7.1 GenPept UniProtKB/Swiss-Prot:F6Q1T7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Research Materials
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