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FGF1 fibroblast growth factor 1 [ Bos taurus (domestic cattle) ]

Gene ID: 281160, updated on 29-Jun-2025
Official Symbol
FGF1provided by VGNC
Official Full Name
fibroblast growth factor 1provided by VGNC
Primary source
VGNC:VGNC:28970
See related
BGD:BT11042; EnsemblRapid:ENSBTAG00070031129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
ECGF; EDGF; aFGF; FGF-1; FGF2B; HBGF-1; EDGF II
Orthologs
human mouse all
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See FGF1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (53622268..53729306, complement)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112447553 Neighboring gene uncharacterized LOC100847454 Neighboring gene sprouty RTK signaling antagonist 4 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene microRNA mir-2460 Neighboring gene Rho GTPase activating protein 26 Neighboring gene uncharacterized LOC132345824 Neighboring gene uncharacterized LOC107132646 Neighboring gene nuclear receptor subfamily 3 group C member 1

Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Complete primary structure of prostatropin, a prostate epithelial cell growth factor. Crabb JW, et al. Biochemistry, 1986 Sep 9. PMID 3768327
  2. Cloning of two different 5' untranslated exons of bovine acidic fibroblast growth factor by the single strand ligation to single-stranded cDNA methodology. Philippe JM, et al. Biochem Biophys Res Commun, 1992 Oct 30. PMID 1280126
  3. Characterization of a bovine acidic FGF cDNA clone and its expression in brain and retina. Alterio J, et al. FEBS Lett, 1988 Dec 19. PMID 2849564
  4. Nucleotide sequence of bovine acidic fibroblast growth factor cDNA. Halley C, et al. Nucleic Acids Res, 1988 Nov 25. PMID 3205724, Free PMC Article
  5. Structural evidence that endothelial cell growth factor beta is the precursor of both endothelial cell growth factor alpha and acidic fibroblast growth factor. Burgess WH, et al. Proc Natl Acad Sci U S A, 1986 Oct. PMID 3532107, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FGF1 and FGF7 may be involved differently in the process of follicle maturation and CL formation, which is strongly dependent on angiogenesis
    Title: Expression of fibroblast growth factor 1 (FGF1) and FGF7 in mature follicles during the periovulatory period after GnRH in the cow.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables fibroblast growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lung development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in wound healing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
fibroblast growth factor 1
Names
acidic eye-derived growth factor II
acidic fibroblast growth factor
endothelial cell growth factor beta and alpha chains
endothelial growth factor
fibroblast growth factor 1 (acidic)
fibroblast growth factor 2B
fibroblast growth factor, acidic
heparin-binding growth factor 1
prostatropin

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001314006.1 → NP_001300935.1  fibroblast growth factor 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC103225, DV846120, EH374181, NKLS02000007
    UniProtKB/Swiss-Prot
    P03968, Q3ZBL8
    UniProtKB/TrEMBL
    A0A7U3JWD0
    Related
    ENSBTAP00070042971.1, ENSBTAT00070070531.1
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  2. NM_174055.3 → NP_776480.1  fibroblast growth factor 1

    See identical proteins and their annotated locations for NP_776480.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    EH374181, NKLS02000007
    UniProtKB/Swiss-Prot
    P03968, Q3ZBL8
    UniProtKB/TrEMBL
    A0A7U3JWD0
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    53622268..53729306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015472279.3 → XP_015327765.1  fibroblast growth factor 1 isoform X2

    Conserved Domains (1) summary
    pfam00167
    Location:25 → 147
    FGF; Fibroblast growth factor

  2. XM_015472275.3 → XP_015327761.1  fibroblast growth factor 1 isoform X1

    UniProtKB/Swiss-Prot
    P03968, Q3ZBL8
    UniProtKB/TrEMBL
    A0A7U3JWD0
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  3. XM_015472276.3 → XP_015327762.1  fibroblast growth factor 1 isoform X1

    UniProtKB/Swiss-Prot
    P03968, Q3ZBL8
    UniProtKB/TrEMBL
    A0A7U3JWD0
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  4. XM_059887924.1 → XP_059743907.1  fibroblast growth factor 1 isoform X1

    UniProtKB/Swiss-Prot
    P03968, Q3ZBL8
    UniProtKB/TrEMBL
    A0A7U3JWD0

  5. XM_024993833.2 → XP_024849601.1  fibroblast growth factor 1 isoform X1

    UniProtKB/Swiss-Prot
    P03968, Q3ZBL8
    UniProtKB/TrEMBL
    A0A7U3JWD0
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  6. XM_024993834.2 → XP_024849602.1  fibroblast growth factor 1 isoform X1

    UniProtKB/Swiss-Prot
    P03968, Q3ZBL8
    UniProtKB/TrEMBL
    A0A7U3JWD0
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  7. XM_015472277.3 → XP_015327763.1  fibroblast growth factor 1 isoform X1

    UniProtKB/Swiss-Prot
    P03968, Q3ZBL8
    UniProtKB/TrEMBL
    A0A7U3JWD0
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  8. XM_015472280.3 → XP_015327766.1  fibroblast growth factor 1 isoform X3

    UniProtKB/TrEMBL
    A0AAF7AQL1
    Related
    ENSBTAP00070042949.1, ENSBTAT00070070506.1
    Conserved Domains (1) summary
    cl00060
    Location:25 → 57
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P03968.2 GenPept UniProtKB/Swiss-Prot:P03968

Gene LinkOut

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