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CTSB cathepsin B [ Bos taurus (domestic cattle) ]

Gene ID: 281105, updated on 5-Sep-2025
Official Symbol
CTSBprovided by VGNC
Official Full Name
cathepsin Bprovided by VGNC
Primary source
VGNC:VGNC:27813
See related
BGD:BT10007; EnsemblRapid:ENSBTAG00070002453
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
CATB
Orthologs
human mouse all
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See CTSB in Genome Data Viewer
Location:
chromosome: 8
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (7566167..7587042)

Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene defensin beta 134 Neighboring gene defensin beta 136 Neighboring gene farnesyl-diphosphate farnesyltransferase 1 Neighboring gene nei like DNA glycosylase 2

Genomic Sequence:
NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Substrate specificity of bovine cathepsin B and its inhibition by CA074, based on crystal structure refinement of the complex. Yamamoto A, et al. J Biochem, 2000 Apr. PMID 10739956
  2. Expression of lysosomal cathepsin B during calf myoblast-myotube differentiation. Characterization of a cDNA encoding bovine cathepsin B. Béchet DM, et al. J Biol Chem, 1991 Jul 25. PMID 1856234
  3. Disulfide bridges of bovine spleen cathepsin B. Baudys M, et al. Biol Chem Hoppe Seyler, 1990 Jun. PMID 2390214
  4. Identification of the second (buried) cysteine residue and of the C-terminal disulfide bridge of bovine spleen cathepsin B. Baudys M, et al. Biol Chem Hoppe Seyler, 1988 May. PMID 3144290
  5. Amino acid sequence of bovine spleen cathepsin B. Meloun B, et al. J Biol Chem, 1988 Jul 5. PMID 3379063

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The cathepsin B deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.
    Title: Cathepsins S, B and L with aminopeptidases display β-secretase activity associated with the pathogenesis of Alzheimer's disease.
  2. The peptides, all of which contain a C-terminal free acid, were tested as inactivators of bovine cathepsin B, in an attempt at exploiting the known and, amongst the cysteine proteinases, unique carboxy dipeptidyl peptidase activity of the protease.
    Title: The inactivation of bovine cathepsin B by novel N-chloro-acetyl-dipeptides: application of the Houghten 'tea bag' methodology to inhibitor synthesis.
  3. evidence shows cathepsin B activity may not be redox regulated; however, the stability of the enzyme at neutral pH is dependent on redox potential, and on the presence of oxidising agents.
    Title: Cathepsin B stability, but not activity, is affected in cysteine:cystine redox buffers.
  4. Overexpressing cathepsin B reduced the Vascular Endothelial Growth Factor-dependent tube response
    Title: Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
cathepsin B
Names
BCSB
NP_776456.1
XP_005209879.1
XP_059744925.1
XP_059744926.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174031.2 → NP_776456.1  cathepsin B precursor

    See identical proteins and their annotated locations for NP_776456.1

    Status: PROVISIONAL

    Source sequence(s)
    L06075
    UniProtKB/Swiss-Prot
    P07688, Q3ZC03
    UniProtKB/TrEMBL
    A0AAA9TG45
    Related
    ENSBTAP00070003342.1, ENSBTAT00070005736.1
    Conserved Domains (2) summary
    cd02620
    Location:81 → 328
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    pfam08127
    Location:26 → 65
    Propeptide_C1; Peptidase family C1 propeptide

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    7566167..7587042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059888942.1 → XP_059744925.1  cathepsin B isoform X1

    UniProtKB/Swiss-Prot
    P07688, Q3ZC03
    UniProtKB/TrEMBL
    A0AAA9TG45

  2. XM_005209822.5 → XP_005209879.1  cathepsin B isoform X1

    See identical proteins and their annotated locations for XP_005209879.1

    UniProtKB/Swiss-Prot
    P07688, Q3ZC03
    UniProtKB/TrEMBL
    A0AAA9TG45
    Related
    ENSBTAP00070003352.1, ENSBTAT00070005751.1
    Conserved Domains (2) summary
    cd02620
    Location:81 → 328
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    pfam08127
    Location:26 → 65
    Propeptide_C1; Peptidase family C1 propeptide

  3. XM_059888943.1 → XP_059744926.1  cathepsin B isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07688.5 GenPept UniProtKB/Swiss-Prot:P07688

Gene LinkOut

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