CCN2 cellular communication network factor 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CCN2provided by VGNC
Official Full Name: cellular communication network factor 2provided by VGNC
Primary source: VGNC:VGNC:27794
See related: BGD:BT12273; EnsemblRapid:ENSBTAG00070015299
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: CTGF
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	9	NC_037336.1 (69887199..69890434, complement)

Chromosome 9 - NC_037336.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of the early growth response-1 binding protein NAB2 in bovine granulosa cells and effect on connective tissue growth factor expression.
Title: Regulation of the early growth response-1 binding protein NAB2 in bovine granulosa cells and effect on connective tissue growth factor expression.
Bovine CCN2 exhibits unique expression patterns during preimplantation development, and is required for the proper expression of key regulatory genes in bovine blastocysts.
Title: Significance of CCN2 expression in bovine preimplantation development.
Results confirm the prodevelopmental actions of activin A and indicate that CTGF may also function as an embryokine by regulating the number of ICM cells in the blastocyst and altering gene expression. Low concentrations of HGF were inhibitory to development.
Title: Actions of activin A, connective tissue growth factor, hepatocyte growth factor and teratocarcinoma-derived growth factor 1 on the development of the bovine preimplantation embryo.
The results indicate that CTGF suppresses the synthesis of biglycan but newly induced that of decorin in the cells when the cell density is low.
Title: Differential regulation of biglycan and decorin synthesis by connective tissue growth factor in cultured vascular endothelial cells.
Actin cytoskeleton-dependent regulation of CTGF transcription and mRNA stability
Title: Regulation of connective tissue growth factor (CTGF/CCN2) gene transcription and mRNA stability in smooth muscle cells. Involvement of RhoA GTPase and p38 MAP kinase and sensitivity to actin dynamics.

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General gene information

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Markers

ECD22450 (e-PCR)
- UniSTS:303436

REN29389 (e-PCR)
- UniSTS:354189

RH35874 (e-PCR)
- UniSTS:6798

CTGF (e-PCR)
- UniSTS:278252

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables integrin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: CCN family member 2

Names: connective tissue growth factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174030.2 → NP_776455.1 CCN family member 2 precursor

See identical proteins and their annotated locations for NP_776455.1

Status: PROVISIONAL

Source sequence(s)

AF000137

Related

ENSBTAP00070020428.1, ENSBTAT00070034555.1

Conserved Domains (4) summary

smart00214
Location:104 → 162

VWC; von Willebrand factor (vWF) type C domain

pfam00219
Location:30 → 82

IGFBP; Insulin-like growth factor binding protein

pfam19035
Location:199 → 242

TSP1_CCN; CCN3 Nov like TSP1 domain

cl21545
Location:253 → 345

GHB_like; Glycoprotein hormone beta chain homologues