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CD3E CD3 epsilon subunit of T-cell receptor complex [ Bos taurus (domestic cattle) ]

Gene ID: 281054, updated on 5-Sep-2025
Official Symbol
CD3Eprovided by VGNC
Official Full Name
CD3 epsilon subunit of T-cell receptor complexprovided by VGNC
Primary source
VGNC:VGNC:27029
See related
BGD:BT25455; EnsemblRapid:ENSBTAG00070030651
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See CD3E in Genome Data Viewer
Location:
chromosome: 15
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (29004581..29015196)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene myelin protein zero like 3 Neighboring gene myelin protein zero like 2 Neighboring gene CD3 delta subunit of T-cell receptor complex Neighboring gene CD3 gamma subunit of T-cell receptor complex

Genomic Sequence:
NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Cloning, sequencing and expression of the bovine CD3 epsilon and TCR-zeta chains, two invariant components of the T-cell receptor complex. Hagens G, et al. Gene, 1996 Mar 9. PMID 8647441
  2. Identification of a bovine surface antigen uniquely expressed on CD4-CD8- T cell receptor gamma/delta+ T lymphocytes. Clevers H, et al. Eur J Immunol, 1990 Apr. PMID 1971793
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive thymic T cell selection IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of alpha-beta T cell receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
T-cell surface glycoprotein CD3 epsilon chain
Names
CD3e molecule, epsilon (CD3-TCR complex)
antigen CD3E, epsilon polypeptide (TiT3 complex)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174011.3 → NP_776436.1  T-cell surface glycoprotein CD3 epsilon chain precursor

    See identical proteins and their annotated locations for NP_776436.1

    Status: PROVISIONAL

    Source sequence(s)
    BC102243
    UniProtKB/Swiss-Prot
    Q28073, Q3ZCH2
    UniProtKB/TrEMBL
    A0AAA9SKR5
    Related
    ENSBTAP00070042332.1, ENSBTAT00070069515.1
    Conserved Domains (2) summary
    smart00077
    Location:170 → 190
    ITAM; Immunoreceptor tyrosine-based activation motif
    pfam16681
    Location:30 → 106
    Ig_5; Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    29004581..29015196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28073.2 GenPept UniProtKB/Swiss-Prot:Q28073

Gene LinkOut

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Research Materials
Miscellaneous