U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CD28 CD28 molecule [ Bos taurus (domestic cattle) ]

Gene ID: 281050, updated on 30-Jan-2025
Official Symbol
CD28provided by VGNC
Official Full Name
CD28 moleculeprovided by VGNC
Primary source
VGNC:VGNC:27021
See related
BGD:BT21134; EnsemblRapid:ENSBTAG00070011029
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See CD28 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (91906337..91939865)

Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene abl interactor 2 Neighboring gene Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 Neighboring gene cytotoxic T-lymphocyte associated protein 4 Neighboring gene inducible T cell costimulator

Genomic Sequence:
NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Cattle CTLA-4, CD28 and chicken CD28 bind CD86: MYPPPY is not conserved in cattle CD28. Parsons KR, et al. Immunogenetics, 1996. PMID 8606060
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in T cell activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in T cell costimulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
T-cell-specific surface glycoprotein CD28
Names
antigen CD28

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181004.1 → NP_851347.1  T-cell-specific surface glycoprotein CD28 precursor

    See identical proteins and their annotated locations for NP_851347.1

    Status: PROVISIONAL

    Source sequence(s)
    X93304
    UniProtKB/Swiss-Prot
    Q28071
    UniProtKB/TrEMBL
    F1MXF4
    Related
    ENSBTAP00070014769.1, ENSBTAT00070024894.1
    Conserved Domains (1) summary
    cd05721
    Location:21 → 135
    IgV_CTLA-4; Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    91906337..91939865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059891286.1 → XP_059747269.1  T-cell-specific surface glycoprotein CD28 isoform X1

    Related
    ENSBTAP00070014775.1, ENSBTAT00070024903.1

  2. XM_024998234.2 → XP_024854002.1  T-cell-specific surface glycoprotein CD28 isoform X2

    UniProtKB/TrEMBL
    F1MXF4
    Related
    ENSBTAP00070014780.1, ENSBTAT00070024911.1
    Conserved Domains (1) summary
    cd05721
    Location:45 → 159
    IgV_CTLA-4; Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28071.1 GenPept UniProtKB/Swiss-Prot:Q28071

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials