CAV1 caveolin 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CAV1provided by VGNC
Official Full Name: caveolin 1provided by VGNC
Primary source: VGNC:VGNC:26799
See related: BGD:BT10178
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	4	NC_037331.1 (51865751..51901396, complement)

Chromosome 4 - NC_037331.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt signaling
Title: Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt signaling.
Data show that resveratrol (Res) reversed caveolin-1 (Cav-1)/endothelial nitric oxide synthase (eNOS) expressions in high glucose cultured bovine aortic endothelial cells (BAECs).
Title: Resveratrol ameliorates high glucose and high-fat/sucrose diet-induced vascular hyperpermeability involving Cav-1/eNOS regulation.
these data provide the first detailed analysis of Cav-1 binding to one of its most significant client proteins, eNOS.
Title: Deciphering the binding of caveolin-1 to client protein endothelial nitric-oxide synthase (eNOS): scaffolding subdomain identification, interaction modeling, and biological significance.
Study identifies a critical role of caveolin-1 in the regulation of eNOS uncoupling via a biopterin-dependent mechanism.
Title: Suppression of eNOS-derived superoxide by caveolin-1: a biopterin-dependent mechanism.
Data indicate that caveolin-1 expression is required for insulin uptake by aortic endothelial cells.
Title: Caveolin-1 is required for vascular endothelial insulin uptake.
These data show that insulin acutely regulates eNOS and CAV-1 trafficking to plasma membrane of vascular endothelial cells where their interaction can regulate eNOS activity.
Title: The trafficking/interaction of eNOS and caveolin-1 induced by insulin modulates endothelial nitric oxide production.
TGF-beta1 downregulates caveolin-1 of cultured endothelial cells, involving ALK-5 receptor subtype
Title: Transforming growth factor-beta1 downregulates caveolin-1 expression and enhances sphingosine 1-phosphate signaling in cultured vascular endothelial cells.
XIAP plays a novel role in endothelial cells, interacting with caveolin-1 and acting as a regulator of vascular antiatherogenic function.
Title: X-linked inhibitor of apoptosis protein is an important regulator of vascular endothelial growth factor-dependent bovine aortic endothelial cell survival.
Phosphorylation of CAV1 in bovine rod outer segments in vitro by an endogenous tyrosine kinase is reported.
Title: Phosphorylation of caveolin-1 in bovine rod outer segments in vitro by an endogenous tyrosine kinase.
caveolin-1 tyrosine 14 phosphorylation has a role in cell adhesion and migration
Title: Reassessing the role of phosphocaveolin-1 in cell adhesion and migration.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

REN66699 (e-PCR)
- UniSTS:391499

ECD05273 (e-PCR)
- UniSTS:286339

REN66821 (e-PCR)
- UniSTS:391621

REN66834 (e-PCR)
- UniSTS:391634

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in caveola assembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info	PubMed
located_in caveola	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info	PubMed
located_in focal adhesion	IEA Inferred from Electronic Annotation more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in sarcolemma	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: caveolin-1

Names: caveolin 1, caveolae protein, 22kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.