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APOE apolipoprotein E [ Bos taurus (cattle) ]

Gene ID: 281004, updated on 12-May-2019

Summary

Official Symbol
APOEprovided by VGNC
Official Full Name
apolipoprotein Eprovided by VGNC
Primary source
VGNC:VGNC:52178
See related
BGD:BT10400; Ensembl:ENSBTAG00000010123
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs

Genomic context

See APOE in Genome Data Viewer
Location:
18q24
Exon count:
5
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 18 NC_037345.1 (52635556..52640577)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 18 AC_000175.1 (53040105..53042793)

Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene nectin cell adhesion molecule 2 Neighboring gene 60S ribosomal protein L15-like Neighboring gene translocase of outer mitochondrial membrane 40 Neighboring gene apolipoprotein C4 Neighboring gene apolipoprotein C2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
amyloid-beta binding ISS
Inferred from Sequence or Structural Similarity
more info
 
heparan sulfate proteoglycan binding ISS
Inferred from Sequence or Structural Similarity
more info
 
heparin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
low-density lipoprotein particle receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cholesterol efflux ISS
Inferred from Sequence or Structural Similarity
more info
 
chylomicron remnant clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
high-density lipoprotein particle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
intermediate-density lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
lipoprotein biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of amyloid fibril formation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of amyloid-beta clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
triglyceride-rich lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
very-low-density lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
high-density lipoprotein particle ISS
Inferred from Sequence or Structural Similarity
more info
 
intermediate-density lipoprotein particle ISS
Inferred from Sequence or Structural Similarity
more info
 
low-density lipoprotein particle ISS
Inferred from Sequence or Structural Similarity
more info
 
very-low-density lipoprotein particle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
apolipoprotein E
Names
apo-E

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173991.2NP_776416.1  apolipoprotein E precursor

    See identical proteins and their annotated locations for NP_776416.1

    Status: PROVISIONAL

    Source sequence(s)
    X64839
    UniProtKB/Swiss-Prot
    Q03247
    Related
    ENSBTAP00000056793.1, ENSBTAT00000086136.1
    Conserved Domains (1) summary
    pfam01442
    Location:85272
    Apolipoprotein; Apolipoprotein A1/A4/E domain

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037345.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    52635556..52640577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024977930.1XP_024833698.1  apolipoprotein E isoform X2

    Conserved Domains (1) summary
    pfam01442
    Location:85272
    Apolipoprotein; Apolipoprotein A1/A4/E domain
  2. XM_005219148.4XP_005219205.2  apolipoprotein E isoform X1

    Conserved Domains (1) summary
    pfam01442
    Location:118305
    Apolipoprotein; Apolipoprotein A1/A4/E domain
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