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AKT1 AKT serine/threonine kinase 1 [ Bos taurus (domestic cattle) ]

Gene ID: 280991, updated on 17-Aug-2024

Summary

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Official Symbol
AKT1provided by VGNC
Official Full Name
AKT serine/threonine kinase 1provided by VGNC
Primary source
VGNC:VGNC:25797
See related
Ensembl:ENSBTAG00000017636
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
AKT
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (69229676..69250154, complement)

Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene adenylosuccinate synthase 1 Neighboring gene SIVA1 apoptosis inducing factor Neighboring gene collagen alpha-1(I) chain Neighboring gene zinc finger and BTB domain containing 42

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of the PI3K-Akt signaling pathway in the developmental competence of bovine oocytes. Andrade GM, et al. PLoS One, 2017. PMID 28922408, Free PMC Article
  2. The phosphoinositide-3-kinase-Akt signaling pathway is important for Staphylococcus aureus internalization by endothelial cells. Oviedo-Boyso J, et al. Infect Immun, 2011 Nov. PMID 21844240, Free PMC Article
  3. Laminar shear stress stimulates vascular smooth muscle cell apoptosis via the Akt pathway. Fitzgerald TN, et al. J Cell Physiol, 2008 Aug. PMID 18247368
  4. TGF-beta2 inhibits AKT activation and FGF-2-induced corneal endothelial cell proliferation. Lu J, et al. Exp Cell Res, 2006 Nov 1. PMID 16963022
  5. Prostaglandin F2α-induced luteolysis involves activation of Signal transducer and activator of transcription 3 and inhibition of AKT signaling in cattle. Rovani MT, et al. Mol Reprod Dev, 2017 Jun. PMID 28337827

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of the PI3K/Akt/mTOR pathway in inflammatory regulation is independent of the activation of TLRs/NF-kappaB. Cross-talk between PI3K/Akt/mTOR and TLRs/NF-kappaB signaling pathways promote inflammation.
    Title: PI3K/Akt/mTOR signaling pathway participates in Streptococcus uberis-induced inflammation in mammary epithelial cells in concert with the classical TLRs/NF-ĸB pathway.
  2. Thus, activation of STAT3 and inactivation of AKT signaling are involved in structural regression of the corpus luteum.
    Title: Prostaglandin F2α-induced luteolysis involves activation of Signal transducer and activator of transcription 3 and inhibition of AKT signaling in cattle.
  3. the measurement of levels of PI3K-Akt pathway components in FCs from ovarian follicles carrying oocytes with distinct developmental competences is a useful tool to identify putative molecular pathways involved in the acquisition of oocyte competence.
    Title: The role of the PI3K-Akt signaling pathway in the developmental competence of bovine oocytes.
  4. These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.
    Title: Protein kinase B is required for follicle-stimulating hormone mediated beta-catenin accumulation and estradiol production in granulosa cells of cattle.
  5. Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt signaling
    Title: Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt signaling.
  6. TG2 contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.
    Title: Tissue transglutaminase promotes serotonin-induced AKT signaling and mitogenesis in pulmonary vascular smooth muscle cells.
  7. results suggest that PI3K-Akt activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta, and NF-kappaB.
    Title: The phosphoinositide-3-kinase-Akt signaling pathway is important for Staphylococcus aureus internalization by endothelial cells.
  8. The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase, reactive oxygen species, and PI3-kinase in stimulated NO release.
    Title: 20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt.
  9. The intracellular mechanism of action of CART in regulation of FSH-induced MAPK signaling.
    Title: Cocaine- and amphetamine-regulated transcript accelerates termination of follicle-stimulating hormone-induced extracellularly regulated kinase 1/2 and Akt activation by regulating the expression and degradation of specific mitogen-activated protein kinase phosphatases in bovine granulosa cells.
  10. AMPK and AKT are both downstream of PI3K and that AKT activation is partially dependent on AMPK. The interrelationship between AMPK and AKT, although known to be individually important in mediating VEGF activation of eNOS, is clearly characterized.
    Title: An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
RAC-alpha serine/threonine-protein kinase
Names
PKB alpha
RAC-PK-alpha
protein kinase B alpha
NP_776411.1
XP_024837360.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173986.2 → NP_776411.1  RAC-alpha serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_776411.1

    Status: PROVISIONAL

    Source sequence(s)
    X61036
    UniProtKB/Swiss-Prot
    Q01314, Q5ER96
    Related
    ENSBTAP00000023461.7, ENSBTAT00000023461.7
    Conserved Domains (4) summary
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124 → 479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
    pfam00069
    Location:150 → 408
    Pkinase; Protein kinase domain
    pfam00169
    Location:6 → 104
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    69229676..69250154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024981592.2 → XP_024837360.1  RAC-alpha serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    Q01314, Q5ER96
    Conserved Domains (2) summary
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124 → 479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01314.2 GenPept UniProtKB/Swiss-Prot:Q01314

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.