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ABAT 4-aminobutyrate aminotransferase [ Bos taurus (cattle) ]

Gene ID: 280969, updated on 21-Jan-2019

Summary

Official Symbol
ABATprovided by VGNC
Official Full Name
4-aminobutyrate aminotransferaseprovided by VGNC
Primary source
VGNC:VGNC:25454
See related
BGD:BT21049; Ensembl:ENSBTAG00000004038
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
GABA-T; GABA-AT; L-AIBAT
Orthologs

Genomic context

See ABAT in Genome Data Viewer
Location:
chromosome: 25
Exon count:
19
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 25 NC_037352.1 (7551560..7641458)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 25 AC_000182.1 (7647414..7689266)

Chromosome 25 - NC_037352.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104970180 Neighboring gene methyltransferase like 22 Neighboring gene transmembrane protein 186 Neighboring gene phosphomannomutase 2

Genomic regions, transcripts, and products

Pathways from BioSystems

General gene information

Homology

Clone Names

  • MGC137464

Gene Ontology Provided by GOA

Function Evidence Code Pubs
(S)-3-amino-2-methylpropionate transaminase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to 4-aminobutyrate transaminase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to 4-aminobutyrate transaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
4-aminobutyrate:2-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
 
iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity NAS
Non-traceable Author Statement
more info
PubMed 
pyridoxal phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
behavioral response to cocaine ISS
Inferred from Sequence or Structural Similarity
more info
 
gamma-aminobutyric acid catabolic process IC
Inferred by Curator
more info
PubMed 
neurotransmitter catabolic process IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
4-aminobutyrate transaminase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
4-aminobutyrate aminotransferase, mitochondrial
Names
(S)-3-amino-2-methylpropionate transaminase
GABA aminotransferase
GABA transaminase
gamma-amino-N-butyrate transaminase
NP_001075050.1
XP_024840408.1
XP_024840410.1
XP_024840411.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081581.1NP_001075050.1  4-aminobutyrate aminotransferase, mitochondrial

    See identical proteins and their annotated locations for NP_001075050.1

    Status: PROVISIONAL

    Source sequence(s)
    BC133277
    UniProtKB/TrEMBL
    A2VDK2
    Related
    ENSBTAP00000073954.1, ENSBTAT00000079455.1
    Conserved Domains (2) summary
    TIGR00699
    Location:34496
    GABAtrns_euk; 4-aminobutyrate aminotransferase, eukaryotic type
    COG0160
    Location:42498
    GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037352.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    7551560..7641458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024984643.1XP_024840411.1  4-aminobutyrate aminotransferase, mitochondrial isoform X1

    Conserved Domains (1) summary
    TIGR00699
    Location:34496
    GABAtrns_euk; 4-aminobutyrate aminotransferase, eukaryotic type
  2. XM_024984640.1XP_024840408.1  4-aminobutyrate aminotransferase, mitochondrial isoform X1

    Conserved Domains (1) summary
    TIGR00699
    Location:34496
    GABAtrns_euk; 4-aminobutyrate aminotransferase, eukaryotic type
  3. XM_024984642.1XP_024840410.1  4-aminobutyrate aminotransferase, mitochondrial isoform X1

    Related
    ENSBTAP00000005280.5, ENSBTAT00000005280.6
    Conserved Domains (1) summary
    TIGR00699
    Location:34496
    GABAtrns_euk; 4-aminobutyrate aminotransferase, eukaryotic type
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